Vyvanse appears to offer considerable benefits over the best seller Adderall, but you must know just a few points to get it right: 
- Vyvanse is an amphetamine, so it is, in essence, the same molecule as Adderall, though not the amphetamine salt mix with some of the adrenergic side effects. No one knows at this moment, but could it be the norepinephrine [NE] in the Adderall? I think so – NE is the only variable other than the rate-limiting step with the prodrug discussed in the previous post on Vyvanse.
- Since the basic molecule is the same, switching is easy, – just don’t follow the *forced dose* titration schedule as noted in the research on the run-up for FDA approval. We don’t do forced dose titration, only researchers looking for the effective parameters should attempt that kind of aggressive titration strategy.
- Practical suggestions for titration strategy with some subtle nuances that will help you get it right if you simply think about these easy details:
- NB: We do not look for a "feeling" that it is working as we did so many years with Adderall – instead we look for clean cognitive changes. Patients will do better, can think better, have better concentration and thinking skills, but don’t "feel that it’s working." If the children who use it continue working, it’s working.
- They, generally speaking, don’t have the same amount of unpleasant side effects: the emotional drop in the PM, the jitteryness, the "squirrelly feeling," the jumpiness, – to use a scientific term.
- The drop in the PM is predominantly cognitive, not affective [emotional]. They may mentally stop, – just can’t work.
- If the dose is too high they may go out the top of the therapeutic window as noted below.
More on the specifics->
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