Posts tagged as:

Celiac

Intuniv for ADHD: Metabolic Challenges

by Dr Charles Parker on February 1, 2010 · 23 comments

Burn Rate Explained

Intuniv, As With Any ADHD Medications: Watch the Burn Rate

Intuniv Posts:
This post is the fifth, with four others, documenting Intuniv Overview, Dosing Details, Drug Interactions and Addiction Indications. Please review all of these posts and the many comments [over 150] on the Overview post to see what readers are saying about Intuniv, this interesting new ADHD non-stimulant medication.

Burn Rate:
If you have been reading CorePsych Blog you will note that I have been writing about my new book, – and the good news, it’s finished, and in edit at this moment – I do hope to get it out by March ‘10. The Patient’s Guide for ADHD Medications: What To Do When Nothing Is Working details an entire chapter on Burn Rate, as everyone who takes ADHD meds should absolutely master the burn rate principle.

This Specific Q & A:
- Is an example of the many Intuniv questions, challenges and positive remarks in these several posts:

Question About 8 yo Boy, Picky Eater and Metabolic Challenges:
“I have just stumbled across you and this site in my research into Intuniv. My son just recently turned 8 and was diagnosed with ADHD this past spring. As I continually read about ADHD kids Luke seems wise beyond his years, is very bright when it comes to building things, or math, and picks things up quickly when he is receiving instruction one on one or in a very small group,- but he struggles in school generally. Long story short, we started with a Central Auditory Processing Disorder diagnosis when he was six.  His primary issue seemed to be language, both receptive and expressive. An exam with an audiologist confirmed a fairly significant CAPD at the time. As he progressed in school it was obvious that ADHD was also a large part of his problems as impulsivity, restlessness, inability to attend, and defiance increased as he got older. We saw a neurologist who, after an EEG, prescribed Focalin XR. This worked like MAGIC, at first.

We started with 5mg and after about a month moved up to 10mg. He was able to focus, concentrate and made great strides in school. His language issues even seemed to improve. Now it seems the Focalin is either failing him or is the wrong drug. His ability to focus has tanked, he has become very impulsive (throwing things, slamming things on his desk) and is increasingly defiant (refuses to do work, follow directions). While other times he seems spaced out, and at home sometimes too compliant, and sometimes melancholy for no reason. With age it seems his receptive language abilities are about right, and at developmental level, but his expressive abilities are still below, which of course is leading to some frustration on his part especially when he is supposed to expressing himself through writing. We were seen by the NP in the neurologist’s office today and she suggested Intuniv. From what I’m reading it sounds like it may work for Luke but she has suggested we stay on the Focalin while we start the Intuniv? Do you agree? (She mentioned d/c’ing the Focalin eventually)

Second, in one of the posts above you mentioned something about “immune dysfunction, bowel challenges and is-he-a-picky-eater”. While Luke is rarely sick, I don’t think he has a solid BM in his life (not watery, but always very, very soft) and he would live on Mac and cheese, peanut butter and jelly and chips if I’d let him. He NEVER willingly tries anything new and is indeed very picky about what he eats. As all of this is very new to me can you shed some light on what this may have to do with anything and what to do about it – or point me to the best place to read about it? We have tried adjusting his diet, etc. in the past but because he is so picky it is very difficult to do.

An Additional Metabolic Point - Headaches
One additional thing that the NP this a.m. more or less ignored – prior to starting meds Luke would wake up in the middle of the night crying and saying his head hurt. He’d be up 30 min. or more, would eventually throw up and then go back to sleep. In the morning you’d never know anything happened. This would happen about once a month from the time he was about 6. I only recall it happening once during the day at school. Once we started Focalin those incidents ceased completely. We had our first return of that 2 nights ago. Any idea what that’s all about? Initially the neurologist said it was “interesting”but had little else to say about it.”

My Answer, Abbreviated To Stay With Metabolism and Burn Rate:
My reaction to this question and many others seen on the many comments on Intuniv and Vyvanse: We must always look at the metabolic hints, the possible changes in metabolic rate before starting the meds. They are subtle but include the following:
- History of bowel issues, too soft, too hard, constipation, diarrhea, monolithic stools, too slow in transit time,
- Developmental delay issues: CAPD, speech issues, Asperger’s, Autism,
- History of Fetal Alcohol exposure
- Headaches, stomach aches, tired all of the time, dark circles under the eyes, pale skin
- Picky Eater
- Not eating breakfast, waking with stomach issues and no appetite
- History of failure with many meds – including stimulants or non-stimulants [Intuniv, Strattera]
- Narrow Therapeutic Window
- History of food allergies even back to early childhood, e.g. “lactose intolerance”
- History of rashes, allergies, asthma, upper respiratory infections, ear infections

If we don’t look at these issues [and more] we cannot predict what the outcome with the medications will be – and every one of these issues can significantly change the underlying metabolic patterns, the amount of neurotransmitters in the body, and the cofactors that burn the neurotransmitters effectively.

Medication management now requires a full awareness of the entire pattern including nutrition [which feeds the amino acid building blocks for neurotransmitters and cofactors], – without more careful questioning at the outset we will have predictable problems – as the burn rate will vary dramatically with all of these variables. Burn rate will effect Duration of Effectiveness [DOE] – dosage patterns and speed of titration at the onset of meds.

Then, if Burn Rate varies, we must always take the next step to measure the immune dysregulations, the neurotransmitters, and the downstream endocrine issues so often found with these upstream irregularities.

Phone Consult Availability
Check out these remarks regarding how to start these reviews with a phone consult: See this post on Intuniv: Comment by Gina Pera on January 29, ‘10 2:30 PM

—>Tweet this post below! For ADHD Medications: Download complimentary white paper Precise Solutions now, – and get ready for the complete version of ‘The Patient’s Guide’ details to follow. Get Neurotransmitter Details Here

{ 23 comments }

More on Celiac ADD and Depression                              Wheatfield

An ADD reader in Germany asked if Gluten Sensitivity could be related to yeast [Candida] overgrowth.

===> My comment:
Many reports show a strong relationship between the two, as the carbs both feed  the Candida overgrowth, and the gluten in the carbs feeds the celiac.

Take a look at this easy review of comorbid conditions and diagnosis of celiac/gluten sensitivity:

===> And on Anemia and Gluten Sensitivity
Also notice the reference to anemia and celiac from Baylor University Medical Center [via PubMed] -and the multiple issues that can occur downstream from allergic reactions to wheat in the bowel.

===> And Regarding Depression with Osteoporosis – 32 yo Male
Then, just saw a person in the office last week from Ohio with "asymptomatic [BM 2x/day, "never a problem"] gluten sensitivity" – very likely silent celiac, [testing underway] and he – at 32 yo – is suffering from "unexplained osteopenia" – actually fractured his heel bone with no significant trauma to the bone, and his bones look, according to his Ohio doc, like he’s a post menopausal woman.

This, dear readers, is a flaming metabolic problem.

Look down at "musculo-skeletal" on this page.
The reference for the osteoporosis connection: Am J Gastroenterol 1994;89: pp.2130-4

ELISA [see overview Why ELISA and 191 references here] and specific nutritional testing [sample here] underway, — also worked up for thyroid, ferritin, glucose and insulin levels, this will be very interesting.

Will get back to you as this evolves.

—>Tweet this post below! For ADHD Medications: Download complimentary white paper Precise Solutions now, – and get ready for the complete version of ‘The Patient’s Guide’ details to follow. Get Neurotransmitter Details Here

{ 6 comments }

SPECT Questioned: Brain Function, Medications and ADD/ADHD Interventions

May 24, 2008 Beyond ADHD

SPECT Brain Imaging: SPECT scans can be helpful with many psych diagnoses, even as basic and commonplace as ADD/ADHD – so why write SPECT studies off as *unproven*?

2 comments Read the full article here →

Aphthous Ulcers/Canker Sores, Gluten Sensitivity and Unmanageable Behavior

May 12, 2008 Beyond ADHD

Report from the Front: The Gluten-Celiac Question
Just in the office last week: An “acting out” child, smart, second grade, unable to respond to medications with two previous docs repeatedly adjusting meds to no avail. She had canker sores.

2 comments Read the full article here →

SPECT Imaging Notes: More On “Celiac Brain” Hypofunction

January 29, 2008 Beyond ADHD

Brain changes do appear on SPECT imaging with immune dysfunction: think gluten sensitivity and celiac. Seeing real pathological evidence, bottom to top, does help with believing.

2 comments Read the full article here →

A Gluten Sensitivity Journal: Useful Notes with Practical Suggestions

December 18, 2007 Autism Spectrum

So many in our offices have more questions about Gluten Free Resources. Try this great magazine, Living Without, to stay informed and continue your personal healing path.

3 comments Read the full article here →

Gluten Sensitivity Beacons: Head, Face and Teeth

October 7, 2007 Beyond ADHD

Brain function diminished by gluten sensitive enteropathy – considered on any level – requires a full appreciation of the obvious facial features that walk into our consulting rooms.

2 comments Read the full article here →

Gluten/Casein Sensitivity: Brain Function Deterioration

September 30, 2007 Beyond ADHD

Brain Function problems show on SPECT imaging downstream from gluten/casein sensitivity. Some can appear psychotic, as we have witnessed in our CorePsych office – and as reported in the Annals of Internal Medicine in that previous post linked above.

2 comments Read the full article here →

Celiac Notes: Opiate Withdrawal from Gluten and Casein?

August 24, 2007 Brain/Body Evidence

You might want to warn gluten sensitive, celiac and casein sensitive patients about this very odd and painful clinical phenomenon: Withdrawal after stopping can be painful, exhausting, and depressing, with weakness, anger, and brain fog.

77 comments Read the full article here →

Why We Overlook Celiac and Gluten Sensitivity

August 13, 2007 Beyond ADHD

This is the first in a series of celiac and gluten sensitivity reports taken directly from an interesting series of posts by Dr Scot Lewey, a gastroenterologist who “gets it” with gluten sensitivity. and regularly reports on the downstream psych and neurological effects.

8 comments Read the full article here →