Posts tagged as:

ADHD

ADHD, Immunity and Gut: Picky Eaters Revisited

by Dr Charles Parker on August 15, 2010 · 5 comments

Thanks for your continued interest in evolving mind/body science! I appreciate your company out here -

Picky Eaters, Like ADHD Folks, Are Not Character Disorders!
If you think you have it bad with ADHD, just throw picky eating into the problem. Then it can become almost untreatable. Those with picky eating problems often [not always!] have significant problems with the North of the GI tract. With the picky eating comes problems with nutrition and immunity that really gums up the works. Immunity creates cytokine problems, and the cytokines then boggle the brain. So let’s do think about picky eating.

We’ve Regularly Visited The South, Let’s Take a Summer Look at the North
I’ve been writing a good deal about immunity and the bowels way down there in the GI South: #2, Transit Time, IBS, Crohn’s – all familiar topics to readers here. Since the bowel is the largest organ dealing with immunity in the body… larger than the respiratory tract and the skin, it’s time we looked at the North as well as the South, and the ubiquitous presentation of picky eating with ADHD presentations. Think immunity! Now, think stomach!

Take a look at this very interesting post on gluten and thyroid, and we can start our deeper conversations about ADHD and immunity. You can’t concentrate… perhaps we need to think a bit more comprehensively. With these new TH-1 and TH-2 understandings we can begin to see that there is far more at stake than just-not-eating-breakfast.

Check out these details on measuring immunity – just a bit away from picky eating: Dr Kharazzian from San Diego on immunity  – from his book Why do I still have thyroid symptoms?

TH-1 is higher than TH-2

A TH-1 dominance may be another reason for negative antibodies. As I explain in the book, we can roughly divide the immune system into two sides. TH-1 is the side that reacts immediately to an invader whereas TH-2 is the delayed response that produces antibodies. In a healthy immune system TH-1 and TH-2 are balanced, however in Hashimoto’s one of these becomes overly dominant. When TH-1 soars too high this suppresses TH-2 and hence antibody production. As a result antibody counts on a lab panel may show as low or negative. When you bring these two systems into balance, however, antibody counts on a panel may temporarily increase before balancing out.

This also explains why the use of iodine can produce a negative antibody panel in Hashimoto’s. Iodine has been shown to stimulate the autoimmune attack against the thyroid, which increases inflammation, a TH-1 response. In a TH-1 dominant person—statistically most people with Hashimoto’s—this further stimulates TH-1 while suppressing TH-2, again producing negative antibody results and giving many the impression the Hashimoto’s has been “cured.” Also, high doses of iodine can stimulate the production of TPO, the enzyme that is the target of autoimmune attack, to the point that it becomes inactive and the autoimmune attack ceases. However TPO is necessary for thyroid function and this is not a desirable approach when we have other methods that work better.

If either of these factors is a possibility, I tell people to check for inflammatory cytokine levels (the compounds that make up the TH-1 system), such as IL-2, IL-12, TNFa, and interferon. They should also check the CD4/CD8 ratio, which is the ratio between T-suppressor and T-helper immune cells. If inflammatory cytokines are high and the CD4/CD8 ratio is out of balance, this indicates an inflammatory condition that is suppressing TH-2 and perhaps artificially producing a negative result for Hashimoto’s. This is especially important to check in those using iodine to address Hashimoto’s.

Why the emphasis on these matters? They all relate back to brain function, for adults and for those with gluten sensitivity as children.
cp

Make sure you take a look at these pages!
ADHD Medication Rules Purchase
“Rules” Affiliate Link
Neuroscience Details

If you found this article interesting please SHARE it:
Bookmark and Share

{ 5 comments }

Lyme Update: New Neuroscience Evidence

by Dr Charles Parker on July 5, 2010 · 1 comment

The blacklegged tick (Ixodes scapularis), the ...

Black-legged Tick - Image via Wikipedia

Lyme Testing Details Are Changing: MyLyme ID, The New Standard
Why should we become very interested in Lyme? Why should those with psychiatric concerns even think about this odd presentation often relegated to infectious disease docs? Simple: Lyme Disease is the Great Imitator, and regularly shows clinically with significant psychiatric presentations from dementia, to depression, to our old friend here at CorePsych Blog: ADHD.

Lyme and Psychiatric Diagnosis
Lyme, in fact, again confirms my underlying proposition that ADHD symptoms often imply more than simple appearances. See the emotional and behavioral implications in this NPLDA Lyme Assessment Form from Robert C. Bransfield, M.D. [Information from patients with late stage neuropsychiatric Lyme disease (NPLD) was entered into a database to serve as a reference point for diagnosis and tracking the patient's status after diagnosis. - Also see this excellent Psychiatric Times article on Lyme and Neuropsychiatric Disorders]

And Dr Bransfield [see his article here on cognitive impairments with Lyme] goes on to say:

All involved with late state Lyme disease agree there is a large amount
of inaccurate information on this subject. This disagreement exists at every
level – journals, scientific meetings, clinical practice, media outlets,
etc. (17,18,19) Some of this disagreement can best be viewed as the normal
difference of opinion seen when scientists approach a very complex problem
from a very different perspective. To fuel the intensity of these disputes,
some approach these issues with a significant bias. The full recognition of
this illness has implications, which could effect tourism, real estate
values, disability, insurance company/managed care liability, workman’s
compensation cases, motor vehicle issues, some criminal cases, and political
issues. Bias issues can adversely effect patient care, research funding, and
medical regulatory issues. Some of those previously impacted by bias now
have difficulty approaching this disease with full-unhampered objectivity.

Lyme disease is clearly a very complex disease. When considering a
similar spirochete disease, syphilis, it has been said, “To know syphilis is
to know medicine.” However, to know Lyme disease is not only to know
medicine but also neurology, psychiatry, politics, economics, and law
.

And from Wikipedia:

Diffuse white matter pathology can disrupt these ubiquitous gray matter connections and could account for deficits in attention, memory, visuospatial ability, complex cognition, and emotional status. (Did I leave anything out? – And see this Wiki link also for SPECT imaging implications diagnostically.)

Other Excellent Lyme Resources:
Dr Kenneth Singleton: the Lyme Disease Solution – see page 58 for psychiatric conditions.
Check out this website for the Lyme Disease Association.
International Lyme and Associated Diseases Society website.

New NeuroScience testing with MyLyme ID The first comprehensive laboratory assessment tool.
Now we have to get more serious, for those already deeply into the long-term implications of less comprehensive testing.

The combination of B. burgdorferi (Lyme) specific memory T cell response and cytokine analysis, in conjunction with standard western blot, provides both cellular and humoral [blood] immune response, as well as patient inflammatory response assessment.  This comprehensive assessment provides the most complete clinical analysis of infection status and immune response that can be utilized to guide therapeutic intervention protocols. Review this relevant reference on LLT-MELISA Lyme from ScienceDirect June ’06.

MY Lyme Immune I.D.™ Comprehensive Assessment (#5652) Includes:
1. —- Immune Tolerance Test® (ITT®)
Identifies memory T cell response specific for B. burgdorferi (Lyme) antigens, even “hidden” or low levels.
Includes a panel of B. burgdorferi (Lyme) specific antigens that offer early and late stage identification.

The specific antigens:
OspC     – Early antigen appears shortly after tick bite or transfer of the spirochete
p41        – Early and late antigen that provides mobility to the spirochete
VlsE-1   – Late antigen appears after spirochete infection
p100     – Late stage antigen
DbpA    – Essential protein needed for overall virulence

2. —- Cytokine Analysis
Analysis of B. burgdorferi (Lyme) antigen specific inflammatory immune response in patients.
Provides guidance for effective intervention protocols.
Assessment includes cytokines, chemokines, and immune growth factors:
IL-1β        IL-6        IL-8        IL-10        G-CSF        IFN-g        TNF-α

3. —- Western Blot Analysis (IgG and IgM)
Western Blot is the industry standard methodology – already frequently used.

It appears that this new level of testing will bring more clear evidence to the diagnostic table. Interestingly, the opportunity for application of even more comprehensive neurotransmitter and hormonal testing will add more interventions to the clinical treatment process.

Do drop a comment and share the details of your take on this new MyLyme testing – or your take on testing in general!

Do take a look at this video on the problem of missed Lyme and the Lyme movie Under Our Skin here on You Tube.
cp

Make sure you take a look at these pages!
ADHD Medication Rules Purchase
“Rules” Affiliate Link
Neuroscience Details

If you found this article interesting please SHARE it:
Bookmark and Share

{ 1 comment }

ADHD Medication Rules: What To Do

April 18, 2010 Beyond ADHD

Because we already know each other I am sending this out to give you a heads up on a forthcoming special pre-publication offer with – ADHD Medication Rules: What To Do When Nothing Is Working -

10 comments Read the full article here →

Psychiatric Diagnosis and DSM 5: Maps to Nowhere

February 13, 2010 Beyond ADHD

If you are lost, forget being found with this bible. Don’t be worried, you won’t have to change anything you are doing… it’s the same old 19th Century stuff, trimmed up to tweak the descriptive language, with no improvements there for patient care, and no new science. Boring.

25 comments Read the full article here →

Brain News: CorePsych Radio Availability

August 6, 2009 Beyond ADHD

Increased Availability with CorePsych Radio Programs- Heads up for many more CorePsych Radio program choices

3 comments Read the full article here →

Pristiq For Major Depression – Clinical Details on CorePsych Radio

July 8, 2009 Bipolar

Some think that Pristiq is just another Effexor XR – but they aren’t thinking about the details.

0 comments Read the full article here →

ADHD Medical Ambiguity: Medical Treatment Can Encourage Denial

January 7, 2009 Beyond ADHD

ADHD Denial is Pervasive: Both The Public and Some Medical Treatment Contributes to ADHD Denial – several aspects of the current medical diagnostic and treatment grid can also contribute to ADHD denial.

0 comments Read the full article here →

ADD ADHD Medications – Amphetamines: 2D6 Drug Interaction Update

December 21, 2008 Beyond ADHD

ADD, ADHD Update: We know Prozac and Paxil commonly interact with amphetamines [AMP] Now we should also watch for Antihistamines as well, see this article.

24 comments Read the full article here →

101 Fascinating Brain Blogs: An Excellent Review

December 11, 2008 Brain Injury

Brain information continues to mushroom: Many excellent brain blogs keep all of us posted on these interesting neuroscience developments. Alisa Miller has reviewed and published an inclusive summary “101 Fascinating Brain Blogs” over at the Online Educational Database [OEDb] for our mutual use and Holiday reading.

4 comments Read the full article here →

ADD, ADHD Medications: Immediate Release Stimulants – Cheap and Low Compliance

December 4, 2008 Beyond ADHD

So, why do some continue to fool around with IR [Immediate Release] meds? – Money talks, their money.
See the 7 Tips on how to understand better IR Stimulant titration strategies for ADD ADHD medications, soon at EzineArticles.com

4 comments Read the full article here →