Neuroscience Details
Watching the Storm - gato-gato-gato flicker
Neuroscience Evidence: Changes Thinking
First:
- If you’re on the skeptical side read this paper first: Neurotransmitters Excreted in the Urine as Biomarkers of Nervous System Activity – Validity and Clinical Applicability
- Download this pdf: Neurotransmission is more than The Synapse
- This first Video Helps Understand How Neurotransmitters Function
- Watch This Brief Video to Understand The Synapse Itself
- This Video Describes The Connections Between Neurons and Synapses
- Review This Brief Video on Excitatory and Inhibitory Interactions
- This PowerPoint Slide Show: Neurotransmitters-Role-in-Health-2008-PPT – Describes How Each Neurotransmitter Works in More Detail
- This Deeper Video Discusses Action Potential – The Way Neurotransmission Takes Place
Neuro-Endocrine-Immune Connections
The evidence is compelling and useful for presentations from ADHD to Addiction, to Brain Injury and Bipolar Disorder. All three of these systems significantly effect brain function. Read on to differentiate how neuroscientists are approaching the problem of accurate measurement – and how measurement leads to specific neurotransmitter balancing activities in the office.
At CorePsych we use NeuroScience Inc for Neurotransmitter, Hormone and Immune testing [CLIA Certified].
Brain evidence moves from the synaptic to the presynaptic, to extrasynaptic, to presynaptic modifiers, to presynaptic precursors. Neurotransmitters can be measured as biomarkers and specifically corrected.
Brain and Immunity
Why and How Immunity Becomes a Stealth Brain Problem – Cytokine Messenger Systems
- Select one of these CorePsych Recommended Books especially the first listed book and CD by Mark Laponis MD, Corporate Medical Director of the several Canyon Ranches on Immunity, Aging and Ultimate Longevity.
Start: Neurotransmitter Introductory Webinar:
- Dr Bradley Bush: Neurotransmitters, Stress, Brain, Kidney and the system for neurotransmitter evaluation – including how-to directions with the testing etc. Excellent resource at the outset of the evaluation process.
Neuroscience Details and References:
- Start: Gottfried Kellerman PhD, CEO at NeuroScience presents a webinar overview of Neurology-Endocrinology-Immunology and Mental Health: How these three measurable systems communicate with each other to contribute to biologically based core psych imbalances.
- Clinician Webinars for Detailed Training from Neuroscience – Slides and Audio
- Product List: Linked details at NeuroScience – and Quick Reference Chart
- Tests and Instructions how to get them done
- Quick Reference on Findings how to interpret
- Product List Describes the products in detail
- Urinary Neurotransmitter Analysis as a Biomarker for Psychiatric Disorders: Biomarkers for Diagnosis – pdf download [70 pgs 26 refs]
- Neurotransmitter Myths and Misconceptions: Neurotransmitter Myths in pdf
-Autism Article: Neuroimmunology of Autism Spectrum Disorder 4 pages multiple references, excellent review, connecting neurotransmitter issues with immune dysfunction.
- Neurotransmitters Role in Health 2008 PPT
- Saliva vs Serum Hormone Levels pdf
- Metal Sensitivity Testing Research – Validity-of-MELISA. for Metal Sensitivity Testing pdf
Metametrix Neurotransmitter Assessment - An internationally recognized, CLIA certified Lab we use at CorePsych for other specific tests.
- Take a look at this page for Patient Information Orientation
- Prepaid Insurance Filing Instructions pdf
- Strongly Recommended How To: Cass Nelson-Dooley MS - Laboratory evidence for Depression, Fatigue, Migraine – Video/slides 27 min
- Amino Acid Profiling 9 pg pdf: Amino Acid Measurements and Recommendations
- Excellent Immunity Review: Understanding-IgG4-Food-Sensitivities
- Information on Amino Acid Testing: Amino Acids at Metametrix
- Information on Triad Profile: Nutritional, Amino Acids and Antibody Assessment: Triad Details pdf
- Information on GI Effects Stool Profile: Bacteria, Immune Dysfunction, Gut Function: Bowel Review pdf
- Women’s Health Profile: Estrogen and Aging: Women’s Health pdf
- Details on Good and Bad Estrogen: Cancer Risk Assessment: Estronex Estrogen Profile pdf
- Metametrix Testing References – specific documentation to validate each test protocol
NeuroAssist.com Another Site with Neurotransmitter References
- With just a bit of digging around you will see that debate exists about which way to go, what to do clinically with measurement of neurotransmitters. In an effort to provide fair and balanced remarks I am including these other references from Marty Hinz MD who disagrees with the NeuroScience protocols discussed above.
- My reaction to this measurement discussion at this moment: Let’s first use these findings as biomarkers and see who is right regarding office protocol and patient compliance – my office experience encourages the use of urinary amino acids as biomarkers, with the absolutely necessary inclusion of measurements for the immune and endocrine systems as clinically indicated.
- My practice position at this time: specific evidence first, then treatment, - I don’t agree that the first line should be a simple trial of non-targeted amino acid precursors as suggested by Dr Hinz, but I am looking forward to spending more time with his training to further understand the nuances of his neurophysiologic insights. Clients that I see in my office are skeptical about this new application of neuroscience in the first place, they want up-front evidence, and appreciate the biomarker assessments measured before any planned intervention with meds or amino acid neurotransmitter precursors. I personally have had considerable success using the NeuroScience model of inquiry – am simply trying to find the best, most predictable path at this moment for concerned patients. If NeuroScience proves ineffective, I will change what I am currently doing. My patients request: show me the details first.
- And for those nay-sayers who think Dr Kellerman is not sufficiently peer-reviewed, I would counter saying simply: See his references listed here and elsewhere. Look at the abundance of references on the NeuroScience site. Neuroscience testings work in my office remarkably consistently with no harm, and surprisingly predictable responses with the recommended treatments.
- Important Note: Neurotransmitter precursor measurement and correction are simply not the only answer to complex issues, as multiple dysregulatioins need to be completely evaluated, another strong point supporting NeuroScience’s comprehensive overview of neurotransmitter challenges including endocrine & immune testing . Complex presentations require more evolved evidence.
- Paper on Neurotransmitter Testing by Trachte et al, Serotonin & Dopamine Precursors Measured in Human Population
- Paper on Depression & Neurotransmitter Precursors in Diet Johns Hopkins Chapter 29-Depression: by Kohlstadt, I, Hinz, M
Neurogistics More Neurotransmitter References
- Paper on Neurotransmitter Balancing – Townsend Letter: Neurotransmitter Balancing pdf
- More references on Neurotransmitter Testing Applications: Testing Urinary Neurotransmitters pdf
Related articles by Zemanta
- Brain Imaging May Identify Autism (inquisitr.com)
- ADHD Medications: Neurotransmitters to the Rescue (corepsychblog.com)
- Neuron connections seen in 3-D (scienceblog.com)
- NEI Guided Nutrition Program(TM) is Second Entrant in Medical Arsenal … – Forbes (forbes.com)
Make sure you take a look at these pages!
ADHD Medication Rules Purchase
“Rules” Affiliate Link
Neuroscience Details
Link to this page
{ 18 comments… read them below or add one }
Dr. Parker, I have posted a couple of times with questions regarding my son’s Intuniv dosage etc but I have a different question this time. I think we’ve decided that we’d like to do Neurotransmitter testing. He’s 8 – taking Vyvanse which works well for his focus and attention at school. There is a drastic difference in the time period when the Vyvanse is working and when it isn’t (mornings especially). It was kinda like the school was seeing the benefits but we weren’t seeing them at home. So, we added Intuniv hoping to get more of a 24-hr benefit from the medicine and it does help. But, that being said, even being on both medications, he still has a large amount of impulsivity. And, he’s still very argumentative alot of the time. Alot of anger. And a very low frustration level. He’s easily frustrated when he has trouble doing anything – to the point of yelling, screaming, using inappropriate language. Any attempt to calm him down only makes it worse. To make a long story short – we feel we’re not getting the full benefit from the medication and feel there may be more going on here. I’ve been visiting your site and following your posts for over a year, toying with the idea of neurotransmitter testing. What would we need to do if we’d like to do it? Thanks!
Tracey,
We make it very simple with a call or email connection to my Patient Care Coordinator at this link. Email or phone, she will be there on Mon @ 8.30 AM EDT.
I do look forward to chatting, surprising how much work can be done over the phone!
cp
Thanks! My test kit is on its way.
Hi Tracey,
I could have written your post. Same meds, same troubles with emotional outbursts and arguing. I have my test kit and am getting my sample tomorrow morning and will send it off! Would love to hear your progress. Dr. Parker, I have an E-mail coming to you, thanks for all your help! And can’t wait to download your new book!
Denise
Hi Denise, sorry it took a while to answer your post. I haven’t been on in a while. Since my last post we have stopped Logan’s Vyvanse completely and it has helped alot with the emotional outbursts and with the anxiety. We never thought that the Vyvanse could be contrubuting to both of these but it definitely appears that it was. Since stopping the Vyvanse, he no longer needs to take the Melatonin at night to go to sleep. He’s taking 3mg Intuniv and that’s it now. We were giving it to him in the a.m. but he was getting overly tired in the early evening (around 5 pm) – He would fall asleep in the car on the way to karate and then have to fight to say awake in class. So, on the advice of his doctor, we decided to try giving it to hm in the afternoon around 3:30 to see if that helped. We’ve only been doing that for two days so the jury’s still out. It does appear that it has solved the late afternoon “can’t hold his eyes open” problem but now, tonight, he had a really hard time falling asleep and he has been really wired (too much so) for the past 2 days. So, now I question whether the better answer would have been to leave the time in the a.m. but to cut back on the dosage…?? His doc said that would be the next step if switching it to the p.m. didn’t have the desired effect. I never expected just changing from a.m. to p.m. would cause such a marked difference in his behavior.
Dr. Parker, any advice? Also, I sent his urine and saliva samples back at least 3 weeks ago and haven’t heard anything yet. Does it usually take this long? I eagerly awaiting the results! Thanks! Tracey
Tracey,
Takes about three weeks for the testing, – you will likely hear about the results quite soon.
- Agree with your doc on the meds, but expect the real answer will be with the NS results: expect Histamine up and need for IgG review.
cp
Dr. Parker, since my phone consultation with you a couple of weeks ago, I have received the supplements and Logan has been taking them for 5 days now. His mood has definitely improved and he is less anxious…also big improvements in behavior. Is it possible that we can see improvement so quickly?
Dr. Parker, Can we use protein powders along with any of the supplements? Our son is trying to eat more healthy and gain some weight , smoothies are something he likes in place of junk food. Are there any that you would suggest ? Also there was talk about maybe having a MRI and we need to know is that something we need to setup outside of your office ? Thanks for the help! Kim
Kim,
For SPECT brain imaging we have several handouts on why and how at this CorePsych Services page, down there under the SPECT heading. If you have any questions just leave a note for Ashley when I could call in the evening to discuss options. Brain imaging is useful, interesting, but often may not be necessary to take care to the next steps based on good evidence.
Protein is strongly recommended with the supplements, and we totally agree with limiting junk food. We can often see the results of an unhealthy diet right there on the neurotransmitter testing when we review those findings in detail.
cp
Could you clarify the kind of neurotransmitter tetsing you use. The Neurosresearch & U of Minnesota references indicate that baseline testing is useless and you need to do a 3 step process staring with taking precursors. I am confused.
David,
I do appreciate, as do my patients, the Neurotransmitter [NT] science on the front end, and the practical/clinical usefulness of the overview of NeuroScience in that regard. Evidence is necessary in this new measurement process, and I find that I/we do need those targets, – and with targets we can proceed more specifically. I thought about these two options for many months, and therefore added them here for the public to review.
I continue to find myself very interested in the science of the glomerular [kidney] physiology and added that info from NeuroResearch for the informed folks like yourself.
The jury is out on these matters, as only clinical experience will encourage the adoption of the most favorable insights. For now I am with NeuroScience for the reasons mentioned – and will continue to report improvements and further insights as I become informed from whatever sources.
In two weeks I will be traveling to Atlanta to review the Metametrix view of similar issues, and have considerable respect for their deep view of these matters as well.
We do use the NeuroScience testing, as I am for identifying specific treatment targets, and am uncomfortable with “just take this and we’ll see.” The NeuroResearch process will seem to the client like just selling amino acids without a clear objective.
Thanks
cp
More specific comments loaded on the NeuroScience page about the Marty Hinz position, and my own take on matters near the bottom. Short take: I know there is a dispute, am documenting it, and have posted my opinion.
cp
Thanks for your reply. I will get tests done. I used Concerta for 2.5 years and had the best 2.5 yrs of my life. I laughed and was the centre of a party for the first time in my life. Only problem is I lost my soul! My generousity and compassion disappeared and I rough shod over people. When I stopped the medication I experienced the worst depression and anxiety I’ve ever experienced. For over a year I have been using Omega 6 : 3 at a ratio of 3:1 together with vitamins. It helps my ADD but I have no passion whatsoever. What would you suggest?
Do give Caitlin a call or email here and let’s see if we can connect for an evaluation of the specifics and get that testing done. Look forward to chatting,
cp
Hi,
I live in South Africa. Do you know of anywhere where I can do a neurotransmitter test in SA. I have had a stress test which involved probes on fingers which indicated certain amino acids needed. Would this be similar to what you talk about.
Regards
Neil,
I don’t think the finger probe amino acids represent the neurotransmitters as accurately at the NeuroScience results – as NS hits the specifics of the not-easily-seen levels of neurotransmitters like PEA, norepinephriine, glycine etc. We have sent these tests overseas and have had excellent results with Thailand residents, so it’s just a matter of cost and billing which you could review by checking at NeuroScience.
Over here in the USA they are set up with most insurance companies – I don’t know about their relationships with SA medical/health systems.
Best wishes, drop us a note if we can help out.
cp
Thanks Jeff- Stay tuned for more in-depth on the molecular side of the med question – combining synaptic with pre-synaptic interventions.
cp
Tracey,
Will reply more offline, but am happy to report that often we see significant changes even in one week. Sometimes not, but often some improvement takes place. If no improvement we are missing something.
cp
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