From the category archives:

Brain/Body Evidence

CorePsych Updates: Crossroads

by Dr Charles Parker on March 15, 2010 · 2 comments

Crossroads - Clarksdale, MS

Image by JMazzolaa via Flickr

Notes from the CorePsych road
It’s been busy here, so I’ll take just a moment to keep you updated.

Brief report from the Mississippi Delta:
Imagine this – I took a vacation… The White Boys and Wives Blues Excursion: Five, count them, surprisingly compatible couples in a White Van for a full 7 days, touring up the Blues Highway in the MS Delta from New Orleans, through Natchez, Vicksburg, Yazoo City, Greenwood, Greenville, Clarksdale and Memphis – a memorable trip through a heartland of change. Our guide: a native of Yazoo City who grew up to become an ad man in Va Beach.

We hit many plantations [including Linden where the closing scene from Gone With the Wind was filmed], the Natchez Trace, blues clubs, [most notably Morgan Freeman's Ground Zero Blues Club in Clarksdale, MS], Eudora Welty’s home in Jackson to name just a few. We also stopped for pictures at this Crossroads> in Clarksdale where many of the Delta Blues originals such as Muddy Waters, Howling Wolf, and BB King passed through heading north to Memphis – Highways 61 and 49 both head north out of the dramatic social and economic challenges associated with king cotton. I told you I picked cotton for several years in my childhood, so the trip brought back some interesting memories. If you have the time, The Blues Highway is a trip back in time to an important piece of our collective history.

Changes At CorePsych
1. Good News: I have finished oft mentioned ADHD Medications book! If you haven’t signed up for the notification and discounted special, do so right now, as I plan to have it out in the next 2 weeks.
2. Keep your eyes peeled for the CoreBrain Wellness Store coming very soon – it will facilitate your keeping up with supplements without having to work through our Patient Care Coordinator. It has many bells and whistles, including simple scheduling for appointments, right there on the Internet.
3. I have several interesting training modules that will be available soon -
a. The Brain School 101, a DVD discussing the use of SPECT imaging for diagnosis that makes it easy to understand how SPECT is used effectively.
b. The Impulsive Brain will be on DVD and out soon – all 6 hrs on ADHD, Bipolar, Brain Injury and Addictions.
c. Several CD’s on ADHD, Holistic Psychiatry and the use of neurotransmitter precursors will be available soon – are in production.

Next project: more specific blog postings on the why and how with measuring neurotransmitters and using neurotransmitter precursors to augment challenging psychiatric presentations.
cp

—>Tweet this post below! For ADHD Medications: Download complimentary white paper Precise Solutions now, – and get ready for the complete version of ‘The Patient’s Guide’ details to follow. Get Neurotransmitter Details Here

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Intuniv for ADHD: Metabolic Challenges

by Dr Charles Parker on February 1, 2010 · 23 comments

Burn Rate Explained

Intuniv, As With Any ADHD Medications: Watch the Burn Rate

Intuniv Posts:
This post is the fifth, with four others, documenting Intuniv Overview, Dosing Details, Drug Interactions and Addiction Indications. Please review all of these posts and the many comments [over 150] on the Overview post to see what readers are saying about Intuniv, this interesting new ADHD non-stimulant medication.

Burn Rate:
If you have been reading CorePsych Blog you will note that I have been writing about my new book, – and the good news, it’s finished, and in edit at this moment – I do hope to get it out by March ‘10. The Patient’s Guide for ADHD Medications: What To Do When Nothing Is Working details an entire chapter on Burn Rate, as everyone who takes ADHD meds should absolutely master the burn rate principle.

This Specific Q & A:
- Is an example of the many Intuniv questions, challenges and positive remarks in these several posts:

Question About 8 yo Boy, Picky Eater and Metabolic Challenges:
“I have just stumbled across you and this site in my research into Intuniv. My son just recently turned 8 and was diagnosed with ADHD this past spring. As I continually read about ADHD kids Luke seems wise beyond his years, is very bright when it comes to building things, or math, and picks things up quickly when he is receiving instruction one on one or in a very small group,- but he struggles in school generally. Long story short, we started with a Central Auditory Processing Disorder diagnosis when he was six.  His primary issue seemed to be language, both receptive and expressive. An exam with an audiologist confirmed a fairly significant CAPD at the time. As he progressed in school it was obvious that ADHD was also a large part of his problems as impulsivity, restlessness, inability to attend, and defiance increased as he got older. We saw a neurologist who, after an EEG, prescribed Focalin XR. This worked like MAGIC, at first.

We started with 5mg and after about a month moved up to 10mg. He was able to focus, concentrate and made great strides in school. His language issues even seemed to improve. Now it seems the Focalin is either failing him or is the wrong drug. His ability to focus has tanked, he has become very impulsive (throwing things, slamming things on his desk) and is increasingly defiant (refuses to do work, follow directions). While other times he seems spaced out, and at home sometimes too compliant, and sometimes melancholy for no reason. With age it seems his receptive language abilities are about right, and at developmental level, but his expressive abilities are still below, which of course is leading to some frustration on his part especially when he is supposed to expressing himself through writing. We were seen by the NP in the neurologist’s office today and she suggested Intuniv. From what I’m reading it sounds like it may work for Luke but she has suggested we stay on the Focalin while we start the Intuniv? Do you agree? (She mentioned d/c’ing the Focalin eventually)

Second, in one of the posts above you mentioned something about “immune dysfunction, bowel challenges and is-he-a-picky-eater”. While Luke is rarely sick, I don’t think he has a solid BM in his life (not watery, but always very, very soft) and he would live on Mac and cheese, peanut butter and jelly and chips if I’d let him. He NEVER willingly tries anything new and is indeed very picky about what he eats. As all of this is very new to me can you shed some light on what this may have to do with anything and what to do about it – or point me to the best place to read about it? We have tried adjusting his diet, etc. in the past but because he is so picky it is very difficult to do.

An Additional Metabolic Point - Headaches
One additional thing that the NP this a.m. more or less ignored – prior to starting meds Luke would wake up in the middle of the night crying and saying his head hurt. He’d be up 30 min. or more, would eventually throw up and then go back to sleep. In the morning you’d never know anything happened. This would happen about once a month from the time he was about 6. I only recall it happening once during the day at school. Once we started Focalin those incidents ceased completely. We had our first return of that 2 nights ago. Any idea what that’s all about? Initially the neurologist said it was “interesting”but had little else to say about it.”

My Answer, Abbreviated To Stay With Metabolism and Burn Rate:
My reaction to this question and many others seen on the many comments on Intuniv and Vyvanse: We must always look at the metabolic hints, the possible changes in metabolic rate before starting the meds. They are subtle but include the following:
- History of bowel issues, too soft, too hard, constipation, diarrhea, monolithic stools, too slow in transit time,
- Developmental delay issues: CAPD, speech issues, Asperger’s, Autism,
- History of Fetal Alcohol exposure
- Headaches, stomach aches, tired all of the time, dark circles under the eyes, pale skin
- Picky Eater
- Not eating breakfast, waking with stomach issues and no appetite
- History of failure with many meds – including stimulants or non-stimulants [Intuniv, Strattera]
- Narrow Therapeutic Window
- History of food allergies even back to early childhood, e.g. “lactose intolerance”
- History of rashes, allergies, asthma, upper respiratory infections, ear infections

If we don’t look at these issues [and more] we cannot predict what the outcome with the medications will be – and every one of these issues can significantly change the underlying metabolic patterns, the amount of neurotransmitters in the body, and the cofactors that burn the neurotransmitters effectively.

Medication management now requires a full awareness of the entire pattern including nutrition [which feeds the amino acid building blocks for neurotransmitters and cofactors], – without more careful questioning at the outset we will have predictable problems – as the burn rate will vary dramatically with all of these variables. Burn rate will effect Duration of Effectiveness [DOE] – dosage patterns and speed of titration at the onset of meds.

Then, if Burn Rate varies, we must always take the next step to measure the immune dysregulations, the neurotransmitters, and the downstream endocrine issues so often found with these upstream irregularities.

Phone Consult Availability
Check out these remarks regarding how to start these reviews with a phone consult: See this post on Intuniv: Comment by Gina Pera on January 29, ‘10 2:30 PM

—>Tweet this post below! For ADHD Medications: Download complimentary white paper Precise Solutions now, – and get ready for the complete version of ‘The Patient’s Guide’ details to follow. Get Neurotransmitter Details Here

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Comprehensive Psych Medication Strategies

January 17, 2010 Brain/Body Evidence

We’re Way Beyond Labels at CorePsych – Psychiatric meds simply won’t work if we don’t understand the entire neurotransmitter process. In this new game of pure neurotransmission, numbers matter.

8 comments Read the full article here →

Holistic Psychiatry is CorePsych

January 4, 2010 Beyond ADHD

Neuroscience evidence changes thinking: This January 26 & 27, just a few weeks away, you will have an opportunity to take a deeper step into that change process: The Holistic Health Virtual Conference: Empowering Whole People – I hope you can join me there.

5 comments Read the full article here →

Vyvanse diminishes Memory? Watch The Top of The Therapeutic Window

November 14, 2009 Beyond ADHD

Vyvanse can create memory problems and there are several likely explanations, so let’s review. Most importantly, remember these small Vyvanse
challenges do teach us – they point the way to the next logical intervention for the most effective medication dosage strategies.

21 comments Read the full article here →

Neurotransmitters & Psychiatric Medications: The Turkey Shoot Revisited

November 7, 2009 Brain/Body Evidence

Let’s target the symptoms precisely. The approach of Turkey Season serves as a great reminder for what-not-to-do with psychiatric medications and supplements, and how to consider withdrawal from gluten with neurotransmitters.

13 comments Read the full article here →

Bipolar, Cobra and ADHD: Are We Killing a Hognose Snake?

October 18, 2009 Beyond ADHD

Out in the metaphoric mind-woods? Think you have the diagnosis right? Let’s take a few more minutes to get the specific, correct identification. See what you think about this brief video

31 comments Read the full article here →

Vitamin D3: Swine Flu, Depression, Autism

September 24, 2009 Blog

Vitamin D3 Needs Attention On Several Levels – Just take the time to go through these many Vitamin D3 links, and do watch this video by Dr John Cannell. We have been hearing about the importance of D3 with depression for years, and know that it is directly connected with good thyroid function – now think D3 and Swine Flu

15 comments Read the full article here →

Brains and Genes: Attention And Cognition Spelled Out

September 21, 2009 Autism Spectrum

So you want to know more about ADHD, attention and cognition… and don’t understand all the research on genes as they relate to your brain equipment? Click over here right now…

2 comments Read the full article here →

ADHD Experts: Convenient, Latest ADHD Insights

September 19, 2009 Beyond ADHD

Can’t Make That National ADHD Meeting? – Bring It To Your Home – And the best news: attend live, or attend through the year – anytime you want. National experts on MP3 for that ride to work! The best advantage: great speakers, the latest insights, lowest cost, available for replay.

4 comments Read the full article here →