Neuroscience

by Dr Charles Parker on October 17, 2011 · 3 comments

2797277450 e144f45dfa m4 Neuroscience

Brain Vision Grows Here - gato-gato-gato/Flickr

Neuroscience Evidence: Changes Thinking

First The Brain Details:
This Video Helps Understand How Neurotransmitters Function
Watch This Brief Video to Understand The Synapse
Review This Brief Video on Excitatory and Inhibitory Interactions
This Deeper Video Discusses Action PotentialThe Way Neurotransmission Takes Place

Neuro-Endocrine-Immune Connections
The evidence is compelling and useful for presentations from ADHD to Addiction, to Brain Injury and Bipolar Disorder.

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We use NeuroScience Inc for Neurotransmitter, Hormone and Immune testing.
Brain evidence moves from the synaptic to the presynaptic, to  extrasynaptic, to presynaptic modifiers, to presynaptic precursors. Neurotransmitters can be measured as biomarkers and specifically corrected.

Brain and Immunity
Why and How Immunity Becomes a Stealth Brain Problem
- Select one of these CorePsych Recommended Books especially the first listed book and CD by Mark Laponis MD, Corporate Medical Director of the several Canyon Ranches

Start: Neurotransmitter Introductory Webinar:
- Dr Bradley Bush: Neurotransmitters, Stress, Brain, Kidney and the system for neurotransmitter evaluation – including how-to directions with the testing etc. Excellent resource at the outset of the evaluation process

Neuroscience Details and References:
- Gottfried Kellerman PhD, CEO Presents a webinar overview of Neuro-Endocrine-Immunology and Sleep: How these three measurable systems communicate to contribute to biologically based core psych imbalances.
- Product List: Linked details at NeuroScience – and  Quick Reference Chart
- Tests and Instructions
- Quick Reference on Findings
- Product List
- Urinary Neurotransmitter Analysis as a Biomarker for Psychiatric Disorders: Biomarkers for Diagnosis – pdf download [70 pgs 26 refs]
- Neurotransmitter Myths and Misconceptions:Neurotransmitter Myths in pdf
- Autism Article: Neuroimmunology of Autism Spectrum Disorder 4 pages multiple references, excellent review, connecting neurotransmitter issues with immune dysfunction.
- Neurotransmitters Role in Health 2008 PPT
- Saliva vs Serum Hormone Levels pdf
- Metal Sensitivity Testing Research – Validity-of-MELISA. for Metal Sensitivity Testing pdf

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Metametrix Neurotransmitter Assessment
- Take a look at this page for Patient Information Orientation
- Prepaid Insurance Filing Instructions pdf
- Strongly Recommended How To: Cass Nelson-Dooley MS -  Laboratory evidence for Depression, Fatigue, Migraine – Video/slides 27 min
- Amino Acid Profiling 9 pg pdf: Amino Acid Measurements and Recommendations
- Information on Amino Acid Testing: Amino Acids at Metametrix

- Excellent Immunity Review: Understanding-IgG4-Food-Sensitivities
- Information on Triad Profile: Nutritional, Amino Acids and Antibody Assessment: Triad Details pdf
- Information on GI Effects Stool Profile: Bacteria, Immune Dysfunction, Gut Function: Bowel Review pdf
- Women’s Health Profile: Estrogen and Aging: Women’s Health pdf
- Details on Good and Bad Estrogen: Cancer Risk Assessment: Estronex Estrogen Profile pdf
- Metametrix Testing References – specific documentation to validate each test protocol

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NeuroAssist.com More Neurotransmitter References
-With just a bit of digging around you will see that debate exists about which way to go, what to do clinically with measurement of neurotransmitters. In an effort to provide fair and balanced remarks I am including these other reference from Marty Hinz MD, who disagrees with the NeuroScience protocols discussed above.
- My reaction to this discussion at this moment: Let’s first use these findings as biomarkers and see who is right regarding office protocol and patient compliance – my office experience encourages the use of urinary amino acids as biomarkers.
- My practice position at this time: specific evidence first, then treatment, -  I don’t agree that the first line should be a simple trial of non-targeted amino acid precursors as suggested by Dr Hinz, but I am looking forward to spending more time with his training to further understand the nuances of his neurophysiologic insights. Clients that I see in my office are skeptical about this new science in the first place, want up-front evidence, and appreciate the biomarker assessments. I personally have had considerable success using the NeuroScience model of inquiry – am simply trying to find the best, most predictable path at this moment. If NeuroScience proves ineffective, I will change what I am doing. My patients request: show me the details first.
- And for those nay-sayers who think Dr Kellerman is not sufficiently peer reviewed, I would counter saying simply: See his references listed here and elsewhere. Neuroscience testings work in my office remarkably consistently with no harm, and surprisingly predictable responses with the recommended treatments.
- Important Note: neurotransmitters are simply not the only answer to complex issues, as multiple dysregulatioins need to be completely evaluated, another strong point supporting NeuroScience’s comprehensive overview of neurotransmitter challenges including endocrine & immune testing . Stay tuned…
- Paper on Neurotransmitter Testing by Trachte et al, Serotonin & Dopamine Precursors Measured in Human Population
- Paper on Depression & Neurotransmitter Precursors in Diet johns Hopkins Chapter 29-Depression: by Kohlstadt, I, Hinz, M

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Neurogistics More Neurotransmitter References
- Paper on Neurotransmitter Balancing – Townsend Letter: Neurotransmitter Balancing pdf
- More references on Neurotransmitter Testing Applications: Testing Urinary Neurotransmitters pdf

Watch for updates here!

cp

 Neuroscience

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-I think it's the side effects of the antidepressant I can't handle -- and I seem to experience the less common ones. -I have measured transit, on more than one occasion. It's always been within the 18-24 hr timeline. -Could taking a vitamin d3 supplement in addition to my regular outdoor exercise combined with good diet, really make a big difference with the worry and obsessiveness? I have capsules of 2000 IU and just started taking it today. I may suggest it....thanks. Can you explain Dr. Hinz's position on why they'll do testing after but not before? I read the citations on both sites and I don't understand his "cookie-cutter" process of step1, 2, and 3 interventions. Lastly, what else can be done medically/nutritionally/etc to make the benefits of the meds last almost all or more of the time?

Jessie, The simple reason I can't explain Dr Hinz is because with all his good research and inquiry and his added conclusions it doesn't make sense to treat speculation, period. I can't explain what I can't understand. cp

Dr. Parker, So how does all this work? I've read the references you cite. I just don't know how to talk to my psychiatrist to work on finding better results. I don't really feel comfortable suggesting the testing because it is so cutting edge and we're talking about a dr. who's putting it all out there on the internet. (which, while a good resource, is also a source that adds to confusion and misinformation for so many). I also would not do it without talking to him about it. So....what do I do? My "appearance" symptoms are adhd, obsessiveness and feeling compelled to have things a certain way. When I take adderall, pretty much everything is so much easier. But when someone else is not demanding my attention, I feel my heartbeat more because my mind is clear. Then I worry and obsess over all of this and sometimes (if I don't stop myself) I absorb myself in reading as much research as possible. I also still have my particular worries and obsessions that sometimes lead to panic attacks (which I manage well while the adderall is effective, less so when it's not effective) --- having enough time to finish something, being on time, having any formatting done exactly the way I want for any project, being in crowds, being in new places with new people, asking anyone for a favor or information, understanding all the details of what is going on with me, conversations w/ people. These things have been like this since I was a kid, but in the last couple years I've learned some things to manage them better and can at least identify them now. Other issues -- chronic neck and shoulder pain (since high school...had PT, carpal tunnel test - pinched nerve was identification), chronic ear infections/drainage difficulties since very young childhood and continued sinus difficulties (but not severe, though aggravated by extreme dust), headaches when the neck and sinus pain is worse, rarely feel rested in the morning but even when I feel ok-also rare-it's still difficult to make myself do what i need to (kind of like how everything used to be before taking adderall) and I am as consistent as I can be with sleep hygiene (probably about 50% successful, which is consistent for me). I rarely wake up in the night unless I'm thirsty or hot or worrying about something subconsciously (pretty rare though). I fall asleep usually within 30 minutes of lying down. Sometimes it's harder because of the aches/pains and my head muscles have a hard time relaxing. It helps to have pressure on my head and complete darkness. Let's see what else....The adderall doesn't last long enough (it lasts as long as it's supposed to; it just doesn't cover the whole day. Even the 12-14 on Vyvanse wouldn't be enough hours most days). -I have no food allergies and I doubt any sensitivities as my transit and bm are within the ranges you cite (doesn't mean I never have difficulty, but it's very rare). -I'm 29, female, very regular cycles, generally more irritable and unfocused during that time each month -I eat well (lots of protein & grass fed beef etc, fiber, long chain carbs, fruits/veggies, limited sugar) and work out 4-7 days a week either aerobic or strength/flexibility exercises. -BP with adderall is around 107/75-80. Average HR with adderall is around 85 during the day. Otherwise, RHR is about 60, MHR is 183. -In last year I've dropped a lot of weight, but due to making these lifestyle changes and being more consistent in them. I weigh about 120 now. -my mood is pretty typical and I handle difficulties so much better than I used to. I don't feel sad. I feel slightly frustrated because I can't put the pieces of the puzzle together yet. I'm thankful for all that I do have and am able to do. I feel overwhelmed right now because the last several weeks have just been so incredibly demanding with all that I have to do and I have just been barely surviving. -my B12 came back over 800, thyroid was 2 something, iron was 14 something, vit D was 17 (which is a little low according to what I read). I couldn't give blood last week because my veins were too small, which surprised me because I drink a lot of water (not quite a gallon a day most days). -I'm successful in that I have my own apartment, car, the same teaching job for the last 3 years (I teach 32 1st-3rd graders), do other activities besides school, good friendships. I just stopped taking citalopram this week (10 mg) because I noticed that my teeth had started chattering together sometimes. When I went up to 10 it got worse. It's also worse when the adderall has worn off, or if I'm nervous about something. Early on I had troubles sleeping, but that had ceased. I never noticed anything positive; I took it for about 2 weeks. I've taken other medications and had strong reactions at low doses also, which I gather from reading your info, is a sign of something else going on - usually with the gut. But like I said, the transit etc are within your cited ranges. I can't figure it out! This tremendously long post is an indication of my obsessiveness and I KNOW there is so much here that you can't begin to address it. Your book and your site has been so helpful in these months of sorting through things. I know I won't have perfection and that's ok :) but I would like to hear what you have to say in general. I know you like the testing and have had great success with it clinically to guide supplements along with medications and to eliminate any problem foods. I just feel like Ive done that already, but I still can't figure this out. And I don't know what to say or how to say it to my dr, whom I like and trust (both of which are not easy for me). What else do I need to do to get my life together!!?? Thanks a bunch........!! :) Jessie