ADHD Medication Dosage: Precision Counts

by Dr Charles Parker on May 11, 2011 · 149 comments

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ADHD Medications Require Precise Thinking

These 5 Stimulant Rules Prevent ADHD Medication Disasters:
Many thousands of individuals are treated everyday for ADHD disorders using stimulant meds that don’t last 24 hr, but only last for a portion of the day. So why aren’t we paying attention to those important details for every single person treated for ADHD, every medication dose adjustment, every med check – even if we don’t plan to adjust the meds?

This, my friends, is a national problem of enormous proportions, as the medication adjustment simply is not sufficiently discussed or addressed. It’s amazing to me that so many of these problems exist into 2011! 90% of the questions raised here at CorePsych Blog in all 2555 comments have to do with how-to-use-the-ADHD-meds-correctly. And, of those comments and questions, the predominate questions address dosage. My two most popular posts [in the thousands of views] are Intuniv Dosage Details and Vyvanse Dosage Strategies – I report that with considerable certainty as I just now checked my stats!

ADHD Med Tutorial – Video
My YouTube Video on ADHD Medication Dosage numbers over 4300 views, and when you check it out you will see even more explicit details on this remarkably overlooked subject.

Audio
Then if you want just a brief [10m] audio review, listening to Parker really get on his soapbox about this deplorable state of affairs, take a listen this CinchCast, also available on this post below where you can reTweet it to your coach buddies or your family who is having ongoing problems with ADHD stimulant meds.

Why the problem? No one has set specific dosage strategy guidelines – simple as that.

Rules: The Stimulant 5
1. Know The DOE: Start by knowing the specific expected Duration Of Effectiveness [DOE] for every stimulant medication. These are listed in detail in my book ADHD Medication Rules – Bottom line: Amphetamines [AMP] short acting = 5/6 hr DOE, AMP XR = 10 hr DOE, Methylphenidate [MPH] short acting = 4 hr DOE, MPH extended = 8 hr DOE.  If the med DOE is longer than these numbers the patient is likely out the top of the Therapeutic Window.

2. Use The DOE: Dial the medication in by using only the DOE and expected increase in DOE according to each dosage increase. Vyvanse increase by 10mg = 2 hr longer DOE, Adderall XR increase by 5mg = increase of about 2 hr, MPH is more unpredictable, but an increase on Ritalin LA by 10 mg = about 2 more hr DOE. If “toxic,” out the top of the Window, then lower the dose carefully and check back. Usually the overdose level clears in ~ 3 days.

3. DOE Over Time: Adjust stimulant meds over time based upon the DOE. Each med check, every med check requires a review of the DOE as metabolic variables change, people grow, diets change – and each of these may require change over time. The standard of care in the US for med checks with stimulant meds is quarterly, about every 3 mos. Some pediatricians check biannually or even annually. My own take in this diminished frequency of med checks in practice: inadequate supervision for controlled substances. My take on monthly med checks for stimulants: not indicated, churning the system.

4. DOE Problems: Problems with the DOE arise from multiple causes, from genetic to metabolic, to drug interactions. These problems are simply too numerous to review in this brief posting, but must be addressed as they are often associated with comorbid metabolic variables, not the meds or the ADHD diagnosis itself – sleep, diet, nutrition, breakfast, etc, all covered in detail in ADHD Medication Rules.

5. DOE Reveals Comorbid Diagnosis: Problems with treatment arise from undiagnosed, misdiagnosed comorbid conditions associated with ADHD. For a significant list documented here at CorePsych Blog of the 171 [at last count] comorbid conditions that look like ADHD, may be associated with ADHD, but often don’t improve as they are not purely prefrontal cortex, executive function related – from the underlying neurophysiology.

For the 10m audio – fasten your seat belts…!

I hope this helps explain these important matters to those you counsel, to yourself or your family. Without precision the stimulant problems abound! Please pass this along to your colleagues and do leave a comment below re your take on these DOE stimulant measures.
cp

 

 ADHD Medication Dosage: Precision Counts

Digitally available now at Nook, Kindle, Barnes and Noble.
ADHD Medication Rules – PDF For Your Desktop  
ADHD Medication Rules | Paying Attention To The Meds For Paying Attention – Kindle Version


  • http://www.corepsychblog.com Dr Charles Parker

    I got you covered with another complete answer over at the posting on Immunity Details. On this question it’s more clear that you haven’t dialed in the stimulant consistently enough. Take it for at least 4 days, and if it falls off you need to work with your doc to increase the DOE as you are coasting on the bottom of the window.

    If, on the other hand, you are experiencing the narrow therapeutic window effect, then we’re back, as I pointed out on the other reply, to the metabolic question.
    cp

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @JayParkeroni Hey Jay, get that dose right, watch the DOE and jail becomes a bad memory. No reason not to dial it in correctly, and if the window moves you can fix the dose by unearthing the underlying metabolic challenge. If it moves: measure it!

  • http://www.youtube.com/profile?user=JayParkeroni JayParkeroni

    [..YouTube..] @DrCharlesParker Thanks dawg, you a life saver. By the way, you found me on twitter lol
    I was in jail for the last two days haha, so yeah thanks again! Concerta helps me with impulse control as well, part of the reason I’m gonna need it, considering I end up i jail without it -.-”

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @JayParkeroni If you experience constant needs for changing dosage, whatever psych med you are on, but most importantly the stimulants, you quite likely are suffering with a metabolic challenge in the background – too subtle to be considered a problem. I call this the “Roving Therapeutic Window” and you can learn more about that phenomenon over at CorePsych Blog – search that term there. Best!

  • http://www.youtube.com/profile?user=JayParkeroni JayParkeroni

    [..YouTube..] I’m on concerta for ADHD, and I’m concerned that I keep getting used to the dosage to a point that I feel as though I need to keep moving up in dosages…I’m afraid this will continue and that I will eventually be hitting beyond normal dosages by the time I am, 20.

  • Jackie

    Dr Parker,

    I’ve been loving your recent writings and radio appearances, and could really use your thoughts on my 18-year old daughter’s situation.

    She’s currently on a tiny (5mg) dose of adderall xr, actually generic. All other ADD meds, including Vyvanse and Intuniv seem to depress and/or irritate her, and so far this has been the best med for her. On this low dose she experiences mild improvement in focus for 4-5 hours, then experiences about an hour of strong irritability and restlessness, then is happy again but unfocused for the rest of the day and eve.  A potential kicker is, we had her tested – and she is actually a 2d6 ultra-rapid metabolizer.

    So my questions are:
    - have you seen ultra-rapid metabolizers a) experience more of this kind of rebound? 2) burn through adderall xr this quickly?
    - given her ultra-rapid status, do you think a) raising the dose will improve the DOE?  b) in a typical 5mg=2hr ratio? b) or conversely should she try adding a second pm dose instead?
    - have you seen generic mixed amphetamine salts create more rebound than brand?

    For the coming month our doc has Rx’d brand and written the scrip bid so that while my daughter’s home from college on break, she can try slowly raising the am dose and/or adding a 5mg second dose.

    What do you think? Thanks so much! Jackie

    • http://www.corepsychblog.com Dr Charles Parker

      Jackie
      This is such a great question! Good for you checking out her genetics – you’re a science mom! Here’s the deal in a nutshell, sorry to be so brief, really should do a blog post about this…

      Genetic testing is great but only tells you a portion of the tale. If that was the only contributory problem the answer would be transparent: Crank the dose to reach the correct DOE – been there done that thousands of times.

      But the informed consumer should also be aware that other factors can gum up the neurotransmitter pathways: genetic changes in COMT, the enzyme that turns over catecholamines like dopamine [eg] into their degraded breakdown products, can be defective [= too much dopamine no matter what you do] – or MTHFR genetic polymorphism is also a big deal, as without it more problems can occur with too few NT no matter how many precursors you take, and then taking a look at cytokines and IgG as those guys can also rain on your neurotransmitter parade.

      With refractory response: It’s often more than one variable to pull together an effective solution.

      This is a short answer, but gives you a hint at the complexity of those who don’t turn around as they should. First step for me, one of the highest percentage of returns: correcting immunity issues by measuring IgG.

      Also consider comorbid [as noted carefully in "Rules"] depression. She may not be clinically depressed but in my next book I will be breaking out yet another form of depression beyond Clint Eastwood… I call it political depression – with a clinical negative bounce based upon DA downreg of the 5HT.

      This is a starter, thanks again for a super question, love it!
      cp
      [My first answer on this came out too early in the AM... and misstated the COMT contribution! - Now corrected.]

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @kalikiter1 Right, it sounds like you are already having some problems with duration, often a key sign that either the dose is too much, coming out the top of the window, or that you have some metabolic background noise causing the IR Adderall to burn unpredictably long. That unpredictability could be corrected by assessing and understanding possible challenges that at firs appear sub clinical. – cp

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @kalikiter1 Right, it sounds like you are already having some problems with duration, often a key sign that either the dose is too much, coming out the top of the window, or that you have some metabolic background noise causing the IR Adderall to burn unpredictably long. That unpredictability could be corrected by assessing and understanding possible challenges that at firs appear sub clinical. – cp

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @kalikiter1 Right, it sounds like you are already having some problems with duration, often a key sign that either the dose is too much, coming out the top of the window, or that you have some metabolic background noise causing the IR Adderall to burn unpredictably long. That unpredictability could be corrected by assessing and understanding possible challenges that at firs appear sub clinical. – cp

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @kalikiter1 Right, it sounds like you are already having some problems with duration, often a key sign that either the dose is too much, coming out the top of the window, or that you have some metabolic background noise causing the IR Adderall to burn unpredictably long. That unpredictability could be corrected by assessing and understanding possible challenges that at firs appear sub clinical. – cp

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] @kalikiter1 Right, it sounds like you are already having some problems with duration, often a key sign that either the dose is too much, coming out the top of the window, or that you have some metabolic background noise causing the IR Adderall to burn unpredictably long. That unpredictability could be corrected by assessing and understanding possible challenges that at firs appear sub clinical. – cp

  • http://www.youtube.com/profile?user=kalikiter1 kalikiter1

    [..YouTube..] Wait so is the take home message here, that if you are on IR adderall, switch to XR? I am currently taking 20mg IR’s and have a love hate relationship. The drug has changed my life dramatically, but often times I have a hard time determining appropriate times to take them and will often suffer for it (no sleep til early morning if taken to late). Im curious about asking my doc for xr, but not sure.. My biggest issue is sleep deprivation and somehow I don’t see a XR pill fixing that.

  • http://www.youtube.com/profile?user=kalikiter1 kalikiter1

    [..YouTube..] Wait so is the take home message here, that if you are on IR adderall, switch to XR? I am currently taking 20mg IR’s and have a love hate relationship. The drug has changed my life dramatically, but often times I have a hard time determining appropriate times to take them and will often suffer for it (no sleep til early morning if taken to late). Im curious about asking my doc for xr, but not sure.. My biggest issue is sleep deprivation and somehow I don’t see a XR pill fixing that.

  • http://www.youtube.com/profile?user=kalikiter1 kalikiter1

    [..YouTube..] Wait so is the take home message here, that if you are on IR adderall, switch to XR? I am currently taking 20mg IR’s and have a love hate relationship. The drug has changed my life dramatically, but often times I have a hard time determining appropriate times to take them and will often suffer for it (no sleep til early morning if taken to late). Im curious about asking my doc for xr, but not sure.. My biggest issue is sleep deprivation and somehow I don’t see a XR pill fixing that.

  • http://www.youtube.com/profile?user=kalikiter1 kalikiter1

    [..YouTube..] Wait so is the take home message here, that if you are on IR adderall, switch to XR? I am currently taking 20mg IR’s and have a love hate relationship. The drug has changed my life dramatically, but often times I have a hard time determining appropriate times to take them and will often suffer for it (no sleep til early morning if taken to late). Im curious about asking my doc for xr, but not sure.. My biggest issue is sleep deprivation and somehow I don’t see a XR pill fixing that.

  • http://www.youtube.com/profile?user=kalikiter1 kalikiter1

    [..YouTube..] Wait so is the take home message here, that if you are on IR adderall, switch to XR? I am currently taking 20mg IR’s and have a love hate relationship. The drug has changed my life dramatically, but often times I have a hard time determining appropriate times to take them and will often suffer for it (no sleep til early morning if taken to late). Im curious about asking my doc for xr, but not sure.. My biggest issue is sleep deprivation and somehow I don’t see a XR pill fixing that.

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] Without an exam, without talking to you in detail, I can speculate just a bit: you are either a fast burner, metabolizing the meds too quickly, but more likely do have an associated biomedical issue, likely from the work I have been doing secondary to immunity. Go to CorePsych Blog and type “immunity” or “IgG” into the SEARCH box there for more info.

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] Without an exam, without talking to you in detail, I can speculate just a bit: you are either a fast burner, metabolizing the meds too quickly, but more likely do have an associated biomedical issue, likely from the work I have been doing secondary to immunity. Go to CorePsych Blog and type “immunity” or “IgG” into the SEARCH box there for more info.

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] Without an exam, without talking to you in detail, I can speculate just a bit: you are either a fast burner, metabolizing the meds too quickly, but more likely do have an associated biomedical issue, likely from the work I have been doing secondary to immunity. Go to CorePsych Blog and type “immunity” or “IgG” into the SEARCH box there for more info.

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] Without an exam, without talking to you in detail, I can speculate just a bit: you are either a fast burner, metabolizing the meds too quickly, but more likely do have an associated biomedical issue, likely from the work I have been doing secondary to immunity. Go to CorePsych Blog and type “immunity” or “IgG” into the SEARCH box there for more info.

  • http://www.youtube.com/profile?user=DrCharlesParker DrCharlesParker

    [..YouTube..] Without an exam, without talking to you in detail, I can speculate just a bit: you are either a fast burner, metabolizing the meds too quickly, but more likely do have an associated biomedical issue, likely from the work I have been doing secondary to immunity. Go to CorePsych Blog and type “immunity” or “IgG” into the SEARCH box there for more info.

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