Intuniv for ADHD: Help With Stimulant Side Effects

by Dr Charles Parker on March 20, 2011 · 27 comments

300px Panic attack444 Intuniv for ADHD: Help With Stimulant Side Effects

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Intuniv Answers Even More Challenging ADHD Treatment Questions
You already know this: one can’t go far down the road with most ADHD treatment plans without running up against stimulant side effects. Stimulants, those meds associated most often with either methylphenidate [MPH] or amphetamine [AMP] molecules, often bring associated problems with these excitatory challenges:

- Increased blood pressure
– Increased anxiety [cognitive, mental - and somatic, affective]
– Increased agitation, irritability
– Increased sleep problems, usually dosage related
– Decreased compliance due to the profound effect of immediate release prevalence

Too often many simply can’t take stimulant medications with these several challenges.

ADHD Medication Rules
I wrote ADHD Medication Rules simply because so many do have troubles with the side effects of stimulants, the first line medication – often because they are adjusted without thinking about underlying biomedical issues. The good news is that the Vyvanse, Adderall and MPH products are very helpful, but just as with any medication from aspirin to birth control, dosing strategies become the key challenge in preventing side effects. See this series of videos for ADHD Medication Tutorials regarding the stimulants.

Four Exceedingly Key Intuniv Solutions Straight From The Trenches
I have had several individuals who just can’t deal with the agitation and increased cognitive anxiety with stimulants. Careful dosing just doesn’t solve the problem as you will see from the many Intuniv posts and hundreds of comments there. If you want a more simple review of materials and links you can see a comprehensive page over at Squidoo.com collected there for your reference.

1. Hypertension Resolution/Improvement
I’ve seen an outstandingly good response from some adults with growing blood pressure problems and stimulant meds. Intuniv not only solved the problem by not increasing the blood pressure, but significantly diminishes the associated somatic and cognitive anxiety, and worked better than the stimulant meds first tried.

2. ADHD and Anxiety Resolution/Improvement
Others with refractory anxiety that appears more cognitive than affective, more mental worries than somatic feelings have responded very well to even low dose Intuniv – adults with only 1-2 mg in the AM and it lasts all day, and, yes, it helps with the associated ADHD.

3. ADHD and Sleep Resolution/Improvement
Those children with sleep issues may significantly improve with dosage at night. I know that the first blush of usage recommendation seemed best as dosage in the AM, – and it often does work best after that protein breakfast. But we have seen an increasing number of patients, especially children, who respond so much better with a PM, bed time dose, and still do quite well the next day.

4. Intuniv With Stimulants: Recent Study Out
A recent ADHD study also documents what we have seen in the office – that using the two med types, Intuniv and stimulants, together often will turn the ADHD tide more effectively. Often the sedative, quieting effects of the Intuniv compliment the greater efficacy of the stimulants in some individuals. Careful titration watching both side effect profiles [documented repeatedly in these pages and in the many previous Intuniv posts] will obviate any challenges as the metabolic pathways show no concern about drug interactions. The advantages of one seems to address effectively the side effects of the other with good result. No this will not be the standard of care, but let’s face it, the combination does work well, just as Wellbutrin with Effexor does over in the land of “antidepressant augmentation strategies.”

Interesting new points for treating ADHD – press on… – and do listen to this piece posted on CinchCast recently:

NTk4N2JiOGY2MDRhMCZvZjw15 Intuniv for ADHD: Help With Stimulant Side Effects

cp

 Intuniv for ADHD: Help With Stimulant Side Effects

Digitally available now at Nook, Kindle, Barnes and Noble.
ADHD Medication Rules – PDF For Your Desktop  
ADHD Medication Rules | Paying Attention To The Meds For Paying Attention – Kindle Version


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Romeo, Already on board, many thanks! cp

Dear Dr. It’s a great pleasure to read your blog. I find your post very informative. Thank you for sharing your insights. As a reader, I consider your writing to be a great example of a quality and globally competitive output. It would be a great thrill and honor if you could share your genuine ideas and knowledge to our community, Physician Nexus. With this you can gain 1000 physician readers from over 62 countries on Nexus. We would love for you to visit our community.  It's free, takes seconds, and is designed for physicians only - completely free of industry bias and commercial interests. Best, Romeo Dayanghirang Jr. On behalf of the Physician Nexus Team www.PhysicianNexus.com

Mandy, Yep, is often heritable and likely gluten, but don't be disappointed if gluten alone doesn't cover the problem, as gluten is but one of the main offending antigens. I do like Enterolab, but the testing can be done for less with NeuroScience. cp

Mandy, OJ should not be taken within 1 hr on either side of stimulant meds... it prohibits there passing thru the gastric mucosa... not a prob with Intuniv. cp

Okay, that will be a relief for the juice lovers in the family.  We did have stool and genetic testing done on my husband through Enterolab, and he was positive with a 17 on anti-gliadin IgA, and a positive celiac gene + positive gluten sensitivity gene.  Am I understanding correctly that as he takes care of the gluten in his diet, his med needs/effectiveness of meds will begin to change?  My son tolerates no stimulants, and you stressed to me that it was most likely an immune issue.  I believe I have a clue that it is gluten intolerance, and will have him tested.  

Mandy, Wouldn't be a gluten IN-sensitivity, but a sensitivity - and the blood tests run thru conventional labs simply don't get down the IgG imbalances. NeuroScience has the most cost effective testing, but even then you have to have some clear experience to interpret effectively... as many blow off the IBA [Intestinal Barrier Assessment] Scores if too low - when they are quite significant. cp

Thanks. One other question I have is about Intuniv, Vyvanse, and Orange Juice. All that I read tells me that there should not be an issue taking these two meds with OJ, but we are noticing the meds wear off in the evening when my husband has OJ for breakfast. Just wondering if there are others having problems with this.

Smith6sa, Completely agree - but one quick point: Both the biologic and psychological problems can, and often do, coexsit - and fixing one without the other perpetuates challenging reactions to real life. cp

Hello Dr. Parker, My husband was dx with ADHD about 12 years ago due to academic diffictulties in college. (He is 48 now.) He has only taken 5-10 mg of focalin (not XR) rarely as needed for meetings, etc. until recently. After learning more about ADHD and realizing many behavioral challenges he has might be helped by consistent meds, he is trying intuniv 4 mg and vyvanse 50 mg. (He does have hypertension.) He feels more relaxed on the vyvanse than his previous MP experience, though he liked it too, he says he feels less hyperfocused on AMP. Without meds, he has issues with inflexibility, irritability, being controlling, arguing, paranoia that are just awful, but there was an immediate improvement when we added in the vyvanse. But it didnt last. He now unexpectedly, generally in the morning can get started up possibly worse than his previous behavior. But he goes days without this happening which is nice. I noticed yesterday, when he forgot his meds in the AM, and I took them to him at work about noon, he had no difficulty getting to sleep about 10 PM. That made me hopeful that he may not be reaching the therapeutic window. . . and would benefit from a higher dose of vyvanse? But I am also terrified of increasing the vyvanse dose and making him worse. Any insight?

Mandy, No reason to be "terrified" about the possibility of too much, it's at most a one day event and can be easily corrected by not repeating that one. Best, however, to really drill down on the DOE, really figure out when it's out and go from there. It will be harder whilst using the Intuniv with Vyvanse as Intuniv is ~ 24 hr not less than a half day unless really under- dosed. The combo is good for hypertensive individuals as both side effects are significantly addressed. Go for the 12 hr DOE with Vyvanse and he will likely have a better run. The exception: if he has immune dysfunction, always a confounding factor if present, as simple food sensitivities can unravel the entire treatment process. cp

Thanks, Dr. Parker. He and my son are both allergic to all trees and grasses and have an allergy for every day of the year, but nothing came up as far as food allergies. However, my husband is convinced he has a gluten insensitivity, but his blood tests have come back negative. He would benefit from more extensive testing to make sure, I think.

Since you bring up the metabolic piece I strongly recommend that you chase down those details with IgG testing and a full medical review from thyroid to adrenal... those challenges will *always* make the meds unpredictable!

Inattentive - Just working with this new Discus and trying get on top of comments... No, it wouldn't make it 'more like regular Ritalin.' It might however, as we have pointed out here, help with BP issues. With ups and downs with Ritalin I always think about comorbid depression and evaluate for that comorbidity before making any specific stimulant changes. Thanks for your kind remarks!

Well said Jeff, so much is missed thru this fascination with appearances... This audio note from the first of the year covers it a bit more emphatically: http://icin.ch/33FVc

I think a bit of the head scratching, "Why a fixation on ADD/ADHD?" is a function of the unfortunate label ADD/ADHD. This label does not, in any way, capture the complexity of the disorder and, most importantly, does not in any way capture (or even hint at) the myriad ways in which this disorder can present itself in terms of behavioral issues in school, work, family, in every single aspect of life. Most importantly, we are learning more and more how a sizable chunk of our "social ills" (self-destructive behavior, criminal behavior, etc.) are a result of people with untreated ADHD.

Its become aggravating to find after a couple convincing diagnoses insisting my underlying signs & symptoms were supposed clear hints of evidence something not be right with me, then within that one appointment having psychiatrists declare I'm ADD/ADHD by the time I walk out their door, and come to find out the real issue is even more basic. Personality disorders, or stuble signs of various emotional & behavioral problems, are commonly a result from emotional/psychologicalabuse by an adult onto a child. So maybe since there are reported high numbers of child abuse, instead of jumping to the conclucion some of these people are ADHD and in need of medication as a quick fix, maybe doctors should slow down and listen to the obvious signs of abuse that require different forms of attention and treatment. I could easily be incorrect, simply stating from personal experience.

Smith6sa, The ADHD fascination is simple: ADHD is the most completely misunderstood diagnosis out there, with the greatest abundance of misunderstanding and misapplication of medical interventions, with the most people suffering with this profound almost antiscientific misunderstanding. Institutional, inadequate thinking predominates, even basic science, such as drug interactions, is frequently overlooked, and the multiple implications of mind body interaction are so prevalent as to take my breath away every day in the office. Short and simple: Many are suffering, and the patterns present for evolved understanding of ADHD will ultimately find application in the rest of psychiatric practice - as humans live far beyond the simplicity of appearance-labels. cp

Dr.Parker, I searched the site and mostly saw that there is not a problem combining Concerta and Intuniv, however as I was surfing the site last night, I thought I found a comment on your blog saying that there is one incidence of sudden death with that combo?? Now I can't find it. Can you just confirm if these two are ok together? My son is on 54mg Concerta every morning and has been wonderful on his focus. The doc recommened going on Intuniv in the eveing because we cannot get a handle on the impulsivity. Thank you so much! Denise

Denise, I didn't report it, because if I had I would have remembered it. Concerta blocks 2D6, not 3A4, the pathway for Intuniv - and therefore is not a problem to my knowledge. cp

Dr. Parker, Do you ever recommend sleep studies for your patients? Thanks.

Sara, Absolutely! We try to identify specific sleep issues in every first office visit, frequently rec sleep studies and work with the sleep folks to get the job done. So many people won't put on their CPAP simply because they can't sleep with it, so we get the CPAP on and help with the underlying sleep disorder, including measuring melatonin - and correcting levels there. cp

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