ADD/ADHD Treatment Notes: More on Vyvanse

by Dr Charles Parker on November 12, 2007 · 30 comments

Vyvanse appears to offer considerable benefits over the best seller Adderall, but you must know just a few points to get it right:                                                                                   Angrykid

  1. Vyvanse is an amphetamine, so it is, in essence, the same molecule as Adderall, though not the amphetamine salt mix with some of the adrenergic side effects. No one knows at this moment, but could it be the norepinephrine [NE] in the Adderall? I think so – NE is the only variable other than the  rate-limiting step with the prodrug discussed in the previous post on Vyvanse.
  2. Since the basic molecule is the same, switching is easy, – just don’t follow the *forced dose* titration schedule as noted in the research on the run-up for FDA approval. We don’t do forced dose titration, only researchers looking for the effective parameters should attempt that kind of aggressive titration strategy.
  3. Practical suggestions for titration strategy with some subtle nuances that will help you get it right if you simply think about these easy details:
  • NB: We do not look for a "feeling" that it is working as we did so many years with Adderall – instead we look for clean cognitive changes. Patients will do better, can think better, have better concentration and thinking skills, but don’t "feel that it’s working." If the children who use it continue working, it’s working.
  • They, generally speaking, don’t have the same amount of unpleasant side effects: the emotional drop in the PM, the jitteryness, the "squirrelly feeling," the jumpiness, – to use a scientific term.
  • The drop in the PM is predominantly cognitive, not affective [emotional]. They may mentally stop, – just can’t work.
  • If the dose is too high they may go out the top of the therapeutic window as noted below.

More on the specifics->

So just how do we figure the DOE – the Duration of Effectiveness, – that excellent dosage parameter we have been using for >10 years with Adderall?

Simple: We always ask the question about DOE, because that tells us about customizing the dosing to the individual’s specific metabolism. Remember from previous posts: size does not matter, weight does not matter, only metabolic rate matters. This point is essential and must be understood completely by the entire team.

Look for the top and bottom of the Therapeutic Window [which also helps spell out the DOE]:

  1. The top of the window – simple: too much – with racy side-effects and can’t sleep.
  2. With too much, the person feels buzzed and agitated, and, most importantly, experiences other side effects – that don’t occur for the most part unless the dose is too high. -Doesn’t mean they are bipolar.
  3. Too high means more than 14 hr duration. You give it at 7 AM and it keeps them awake past 10 PM, – often a sign of too much. Stay with ~ 13/14 hr as the objective for the DOE, and do record DOE for every office visit.
  4. With too much, they feel their mind is racing and they actually can’t concentrate.
  5. The bottom of the window, also simple: not enough… it doesn’t work at all, or…
  6. It quits too early, at about 2-3 PM with a drop in cognitive/thinking skills.
  7. The main focus for all of us – not previously appreciated without another PM dose of another short acting med – are those bewitching hours between 4 PM and 8 PM when the goblins appear.
  8. If the dose is right: the PM is covered quite consistently. Interesting… and easy.
  9. Always go slower and lower than you might expect based on the published research numbers, and take a visit or two to get the dose right, about 2-3 weeks later – let it settle to discover it’s metabolic rate.
  10. The redeeming feature: you will get it right faster, it will last at that level. Recent studies show that when adjusted correctly it needs no more attention during the entire following year. Predictability is all about that rate-limiting step that activates the prodrug, peels off that lysine binder,- it actually digests it into action with an enzyme that keeps it from running into your system all at once.
  11. The exemplary outcome… even more predictable action than our previous favorite. This third generation stimulant medication becomes an excellent addition in a sea of unpredictability and constant working with outcomes and side effects with other stimulant meds.

Interestingly, as mentioned in a recent previous post, the adults [off label] have had an excellent experience with Vyvanse as well, with very little titration and fewer office visits to get it right.

And nobody has to feel like they are a drug addict to take it. No buzz, no hype unless they pop out the top of the window based on the dose being too high. One slight exception to this is starting up, so use the slow titration outlined in that same previous post if the person is sensitive to meds. Expect they may be jittery for the first 3-4 days, just hang in there, or divide it in 1/2 with water titration strategy noted in that post.

Remember the study mentioned before with those poor, beat-up methamphetamine addicts in Baltimore…  – they voted on the likability both by mouth and IV quite clearly: "We don’t like this Vyvanse stuff!" It is an amphetamine without many of the amphetamine properties… this is a good thing.

And an important, quick side note: I wonder how many of those amphetamine addicts have ADD? – and even more importantly: how many of them are now treatable because they can’t abuse the drug? This is a very big thing. ADD/ADHD challenges always effect the recovery process and must be identified. If untreated they remain a significant relapse trigger.

-Said it before, will say it again, Vyvanse will change how *the uninformed* think about ADD – but I still recommend you keep your ADD/ADHD diagnosis a secret.

I will keep you posted as understanding regarding Vyvanse use for ADD/ADHD evolves here.

Please send any comments out on this post as you may have some different experiences that will add to the discussion.

Make sure you take a look at these pages!
ADHD Medication Rules Purchase
“Rules” Affiliate Link
Neuroscience Details


Bookmark and Share

Copy the code below to your web site.
x 

{ 30 comments… read them below or add one }

1 Dawn April 14, 2010 at 11:22 AM

Dr Parker:
My son was dx wih ADHD September 2009. He takes 30 mg of vyvanse. He did mildly stutter and it seems since December his stuttering has increased. Their is a family history of stuttering, could his medication be the cause of this increase?

Dawn

Reply

2 Dr Charles Parker April 14, 2010 at 12:27 PM

Dawn,
I don’t have specific references to document downstream effects of stimulant meds re: stuttering. Some studies do exist regarding downstream seizures, and certainly tic disorder, so it does make sense that stimulant could aggravate stuttering.

My take on these matters at this point, and I predict will soon become the standard of care: why not measure what the neurotransmitters are, take a look at the various metabolic factors present, and make some specific corrections to those likely imbalances.
cp

Reply

3 Kim November 17, 2009 at 8:15 PM

Dr. Parker, We are new to using Vyvance for our child. We are on day four, starting with 1/2 titration. He has no problem going to sleep but is waking up at around 4 A.M. and now has difficult time returning to sleep. Sleeping was not a problem prior. This is of course catching up with him at school being sleepy at end of day. Is this temporary? Any suggestions?

Reply

4 Dr Charles Parker November 17, 2009 at 9:24 PM

Kim,
Sleep can be side effect at the outset – and whenever that happens I drop back to a diminished dose – use the water titration to go to 1/4 the dose by dividing the single cap into 4 oz, and then 1 oz/day.
cp

Reply

5 Kim November 18, 2009 at 9:22 PM

DR. Parker, Thank you for your reply that confirms what we thought was correct. Today my child came home and told us he experienced anger like he has never felt before and it scarred him. We are aware that the depression medication being taken could have this side effect and should be reported . We are concerned and want to know if it should be continued?

Reply

6 Dr Charles Parker November 19, 2009 at 6:14 AM

Kim,
Hard call without more info. Yes, your observation could be the case, and if the antidepressant was recently raised that could be the issue. However, in addition review the DOE as all stimulants when topped out tend to cause irritation, esp. AMPs.
cp

Reply

7 aviv September 10, 2009 at 4:24 PM

i suggest to all the first time u taking a pill is to take it very small bit from it and see what happened
and then a bigger one cos i did take the smallest Ritalin pill [10mg] and got over-focus for 4 DAYS!
and then 2 weeks with lite effectiveness from it

Reply

8 Dr Charles Parker September 11, 2009 at 6:14 AM

Aviv,
Yes, always low and slow with stimulant meds. No harm, better, more predictable outcomes, awareness of metabolic rates, better titration accuracy using the DOE.
cp

Reply

9 Kati July 17, 2009 at 4:20 PM

Dr. Parker:

My son was put on Vyvanse by our pediatrician, which we are considering leaving, after having discussions with her, to get her advice with input I was getting from teachers at school on my son who was in the 4/5 grade. His grades were honor roll grades, always, but I was told continuously that he was distracted, couldn’t concentrate, and was distracting other student due to him not sitting still and wanting to chat. My pediatrician prescribed Vyvanse without any suggestion of seeing any other for a diagnosis. We’ve seen her for years and I had a significant amount of trust in this doctor. My son seemed to be much “calmer” on the medicine, but also seemed to go into a “dark” place after being on this medicine for 4 months or so. We went from the 30 mg. to 20 mg. Shortly after switching, SUDDENLY, he developed a motor tic and then some facial tics. NEVER, in is 11 years had there been any signs of any tics at all. NOTHING! He was a great athlete, full of energy, and literally, one night, I hear him upstairs in his room saying a cursing over and over. I was beside myself. I had not heard from school, I assumed nothing was happening. Turns out, that same day, his teacher said he yelled out in class. Something he had never done. Needless to say, he has been taken off the medication, and has been off of it for some 5 months now. Most all tics FINALLY went away. However, now he has a motor tic that has resurfaced as well as a motor tic, no cursing this time, just repeating things over. Our pediatrician indicated that it was likely caused by Vyvanse and that it “should” go away. Any thoughts on how long we can expect these tics to continue? It has not effected his grades at all, but his has effected is confidence and also his athletic ability as he is unable to adequately focus due to his head tic, which often times causes SEVERE headaches.

Thanks so much for your thoughts.

Reply

10 Dr Charles Parker July 18, 2009 at 9:52 AM

Kati
Very unusual, as your ped says, that it would continue. Some tic reactions do occur, are not common, and his appears to be most unusual in severity. Testing before treatment would very likely not have turned up any indication that would warn anyone that this tic disorder was a possibility.

Other contributory, mitigating circumstances might be picky eating, poor breakfasts, immune system dysfunction [bowel issues], depression and possibly genetic predisposition.

Re intervention possibilities:
1. Neurotransmitter precursor measurement and targeted treatment – not a med, amino acids, I would jump on this right away because of the safety factor and some reports that severe tics have responded after years of poor response.
2. Tenex [guanfacine] and the new drug coming out by Shire: Intuniv, [a time release Tenex] has been helpful in tic disorder with some people – [more than simply for oppositional folks - doesn't sound like he is oppositional]. Intuniv is indicated for treatment of ADHD in children and will likely be launched this fall. Tenex is available now.
3. Neurofeedback: Exceedingly good outcomes – in our office we have regularly seen complete resolution of tic disorder with NFB.

In complex presentations I would expect to use all three of these interventions.
This problem is highly likely to be resolved, – just a matter of getting on it.
cp

Reply

11 Jennifer March 23, 2009 at 1:55 AM

Dr. Parker, my 7yr old son was just diagnosed with ADD. He has a difficult time listening, focusing and daydreams a lot. His Dr. started him on 20mg of Vyvanse. He has a hard time swallowing pills so I put the contents of the pill into a small glass of water. He drank the water and had a healthy breakfast. Within, 30-40 minutes he complained of having “weak legs” and was and looked very tired. He soon fell asleep for one hour. After waking, he complained of a stomach ache and headache for the next 6 hrs (still looked like he didn’t have any energy). This is the first med. we have tried for ADD. I only tried it that one day b/c of his symptoms. I was not sure if his reaction to the vyvanse was b/c it was too low or too high. What are your thoughts? He is not on any other medications. Not sure if it is unusual or important to note, but my son gets very talkative/hyper when he takes Benadryl. I was nervous to start ADD meds in the first place b/c he is such a worrier and didn’t want to see him get anymore anxious.

One more thing, my son also is disfluent(stutters) with some secondary characteristics (blocking). It runs in the my side of the family so most likely it will be a on going struggle for him. He is in therapy, but was wondering how the stimulants might affect the stuttering.
Thank you for your time.
Jennifer

Reply

12 Dr Charles Parker March 23, 2009 at 11:44 AM

Jennifer,
This reaction was likely secondary to the med, but the play has just begun:
1. Make sure that he has protein for breakfast – some consider toast and peanut butter “healthy.”
2. Divide the dose in 1/2 following my titration schedule elsewhere here, 20 mg in 2 oz water, 1 oz=10mg – cutting the dose in 1/2.
3. He may simply be a child who can’t take it but I would stay with it until you get 3-4 days into it… most probs are the first week.

The stuttering problem can go either way, I have seen them improve, and sometimes get worse – if worse I really look hard at all the other variables from immune dysfunction to nutritional status etc. I would do all this latter anyway with the stuttering – we used to look at that process only psychologically, then only behaviorally, now full on biologically.

See the immune testing information at Useful References and look around on the LRA by ELISA, the Perque.com site.
cp

Reply

13 Rebecca February 16, 2009 at 2:49 AM

It is worth noting, as I’ve read through some of your other posts, that my son also takes 75 mg of Bendryl per day. It’s something we started long ago to encourage sleep when Melatonin didn’t touch him. Our psychiatrist said it was okay to continue to give it to him as it seems to calm him through the bewitching hours (after 6 pm), but does nothing for his sleep, hence the Clonidine. However, I read more about the 2D6 problems with Vyvanse and antihistamines on another page, and am wondering if that’s why we’ve seen such poor response to the Vyvanse? The effectiveness we saw is about 4 hours total, at which time he is back to full symptoms. Is it possible that the dose of Vyvanse we started him on (30-45 mg) is too high, as is suggested in some of the posts above, when it seems to be completely out of his system within 4 hours, or that the Benadryl inhibitted its absorption? Finally, if we are to start him at a low dose of Vyvanse, like 30 mg, how do we cover for the rest of the day if the first few weeks he’s not at a therapeutic dose? At this point, there is no way he could make it through a whole day of school on just the Vyvanse. Thanks so much for your feedback!

Reply

14 Dr Charles Parker February 20, 2009 at 4:51 AM

Rebecca,
In a word, all of the above… are possible, but unlikely:
1. If the dose is too high the DOE is simply too long and sleep is diminished with bad dreams, assuming no sleep issues before, and appetite is compromised as well.
2. Sleep: Hard to tell without better questioning… Benadryl may help with sleep, most commonly we see sleep hangover and tiredness until 9-10 AM, a reason to start with other products, – but, in truth, it works better for some people. I do like Clonidine, again if it works. Sleep medications should always be adjusted just as the Stim meds, to cover ~ 8hr. If Benadryl was the culprit he would become obviously toxic with all the problems of out the top of the window – don’t think that’s it, and further he’s off Benadryl now.
3. Overview: Using DOE sounds like the dose is too small, even at 45mg. Notice the DOE difference between 30 and 45 and that will give you a clue about next dose with your doc… 50 sounds like it’s unnecessary, already too low, and 60 would be the next step to see if corrected somewhat. You cover the rest of the day by sticking to the DOE guidelines and slowly increasing to cover the bewitching hours, usually 2 week intervals, and usually each 10 mg Vyvanse will increase that DOE about 2 hr – 3 hr.

Over 14 hr DOE almost always too much. If you go slowly you will find the sweet spot, remember breakfast is the deal, and engage your son in the process, with him on board on the objectives, piece of cake, getting him on board can take months depending on many factors. I had a young girl I started with about 11, she hated me all the way thru HS, sneered every visit, embarrassed her mother [father an MD] – just didn’t need the meds, fell on her face every time off. Now is a molecular and cellular physiologist at a prestigious academic site, smiles is grateful, and is well versed in the process. Only at in her Sr year at a strong academic undergrad did she see the light.

Everyone has their own time.

Hope this helps,
cp

Reply

15 Rebecca February 15, 2009 at 12:25 PM

Hi, Dr. Parker–

My son has been on the Daytrana Patch for about 2 years with pretty good response for his ADHD. We decided to try Vyvanse after an appointment with our Psychiatrist where our son demonstrated a complete lack of linear thought processes. He is on a variety of other medication for Asperger’s Syndrome and anxiety, including short-acting Focalin in the morning to cover until the patch becomes effective, Invega for the autism, Clonidine for sleep and Clonazepam for anxiety. In the couple of days on Vyvanse, he has been completely sedated, almost unable to stay awake, for about 4-5 hours, then the meds seem to completely wear off and he is back to full symptoms of ADHD. He is usually a very quick metabolizer who requires relatively high doses for effectiveness–was on 50 mg of Daytrana, following 20 mg of fast-acting Focalin. We started on 30 mg of Vyvanse, then added another 15 after 2 hours when it seemed ineffective. Please advise.

Reply

16 Dr Charles Parker February 20, 2009 at 5:32 AM

Best quick take: Start all over with the Vyvanse-
These symptoms are quite different than described in the previous comment wherein, if the guy is the same guy he appears to not have enough on board.

This set of symptoms sounds like he is on too much. I always start with the assumption that tiredness and sedation ["complete sedation"] – in this post comment the 4 hrs is sedation in the other seems to work for 4 hrs, each question leaves different implications.

With ASD and Asperger’s I always look for immune dysregulation, unpredictable metabolic rates with relative liver metabolic rates slowing leaving toxic and unpredictable outcomes. Don’t know what you have done in that regard, I find the LRA/ELISA very useful, does cost, but provides consistent excellent answers regarding immune dysfunction. Info over on the site on ELISA under Useful References under Browse.

Focalin and Daytrana both use different metabolic pathways, and are not metabolized thru 2D6, often discussed elsewhere here. He may simply be reactive to a genetically slow 2D6, and AMP can’t get thru properly – quickly enough causing problems.

Final note: Best way to work with Vyvanse, just increase the AM dose, don’t try to give other times later in the day. It isn’t built that way, – later doses = big problems with sleep most of the time. Just go up on AM dose under direction of your doc, and watch the DOE as outlined here.

If the reaction continues atypical suggest the other ELISA Workup to hit other metabolic variable.
The article here will be of interest and you can Google LRA/ELISA for more info. Biologic problems need more eval, then things can be more easily corrected. We also do specific nutritional testing to see what needs to be added to the metabolic mix. I love the evidence, makes things more predictable.
thnx.
cp

Reply

17 Dr Charles Parker June 24, 2008 at 4:26 PM

Murphy -
Best to take a look at this link to build a foundation for your concerns -

http://www.corepsychblog.com/2006/12/add_overlooked_.html

There are two types of anxiety, one affective, one cognitive, and the cognitive may be directly associated with a subset of ADD… so that one you will have to take back to your medical team.

And, BTW, they may be interested in reading the post at this link!
cp

Reply

18 murphy June 24, 2008 at 2:18 PM

I am on concerta, for anxiety…. I have been reading in books and on the internet, that it is really for ADD, but what I really have is anxiety not ADD… should I be on concerta?

Reply

19 Dr Charles Parker June 21, 2008 at 5:32 AM

Theresa,
Very complicated case, and if he was a patient in my office some other thoughts do come to mind:

1. What are his patterns with breakfast, food intake, bowel habits, allergies and immune dysfunction symptoms? These are questions not for you to answer here, but these are but a few of the questions I would be asking. In a word, more is going on than simple ADD/ADHD. You may wish to read the paper by Jaffe under Useful References [CorePsych Toolkit to the upper left on this page]: immune dysfunction for background… I don’t recall that the paper mentions tic disorder specifically, but you can see better where I am going with this answer. Bottom line: more comprehensive evidence is available, and necessary to unearth the next steps in this complicated presentation.

2. Tenex often helps with tic disorder, but I see tic disorder as a tip of a neurological/metabolic conundrum that needs more than simple psych meds, and that underlying problem may in fact be related to the ADD and associated symptoms as well. Psych meds help, but won’t fix the underlying problem.

3. You are on the right track, ped neurologist should be the next step.

4. And one other effective intervention that does not exclude working with meds, and with metabolic, – our trusted tic intervention process: neurofeedback. We have had many good results with this combo of interventions. Google Neurofeedback and find providers near you.

5. My best advice, leave no stone unturned, keep looking, there are available answers for this presentation.

Best of luck,
Do keep us posted on what the neurologist says-
cp

Reply

20 Theresa June 20, 2008 at 7:53 PM

Dr. Parker-

My son has tried a plethora of meds. The adderall w/had negative rebound effects but no tics (I did not try giving a 2nd dose later in the day,however, which may have helped at the time). Later, we tried Concerta (18 mg)–severe whistling tics started a week later. His doctor took him off immediately and the tics cleared in another week. Did the Straterra thing and after a month night terrors occured at 10p 5-6 nights/wk. So then he went back to Metadate CD (10mg) which made me nervous due to tics…a month later tics started and this time the doctor said it may just be underlying tics and stay on it for a few months…we continued for 2 mos. and the tics morphed and became more frequent–we switched to 30 mg Vyvanse w/only a 5 day break in between the Metadate and Vyvanse. The Vyvanse was great for everything except the tics continued, Risperdal prescribed (.25 mg). Only helped tics by 25% and they just morphed in breating tics. After school was out for summer took him off Vyvanse, while remaining on Risperdal a few days later–the tics looking more like tourettes (though he has never been a vocal or facial tic kid) and said he wanted to kick his legs. Took him off Risperdal and the leg kicking ceased. However, it’s now 7 days later and tics are somewhat better but does odd cough sound and still yells out his words now and then and adhd symptoms seem worse than previous summers. Why didn’t he get any tics the 9 months on Adderall a few years ago but did w/Vyvanse? Why does he seem more immature than 4 mos. ago when he wasn’t on anything? Any help would be appreciated. He has an appt. w/ped. neurologist in a few months but wanted your input.

Reply

21 Denise Claude February 16, 2010 at 3:41 PM

Hi Theresa, My name is Denise and my son has experienced the same issues with the tics on Vyvanse, i was wondering if you have talked to any representation to see what your options were about this unfamiliar severe side affect. I would appreciate it if you would get back to me asap. Thank you!

Reply

22 Dr Charles Parker February 19, 2010 at 5:10 AM

Denise,
Amphetamine products and methylphenidate products can both show tic side effects. Often these side effects can be modified by using Intuniv with the Vyvanse, but quite often require their own set of separate intervention strategies – including going off the stimulants, and obtaining clear neurotransmitter biomarker results.

That neurotransmitter information has proved useful in many children with tic disorder. Most commonly seen as you would suppose, an increase in excitatory neurotransmitters and significant immune dysfunction – casein is an antigen often associated, as is gluten. If you don’t look you can’t see.
cp

Reply

23 Dr Charles Parker March 8, 2008 at 10:16 AM

Jerry,
Inappropriate to give you advice without seeing you… Take a look at this post and you will likely find some of your situation there.

http://www.corepsychblog.com/2008/01/tips-on-medicat.html

I would go back to your doctor, go lower and slower and titrate more carefully looking for cognitive not affective improvement. All of these symptoms sound like those in my office of too much medication, out the top of the window.

I will leave that to your doc and you. I will bet you aren’t sleeping well, have lost your appetite, and have more swings than you have had before, even depression.

If so, it is too much, suggest you consider with your doc: as noted, start over, and go more slowly-

cp

Reply

24 Jerry March 6, 2008 at 2:22 PM

Hi- Hoping someone can give me there advice.

I was diagnosed with adult ADHD a month ago, I’m 34 yrs old. Started on Vyvanse about 3 weeks ago. First week was great. Able to focus, prioritize tasks and get a lot of work done. But then after 1st week I started to crash so doctor increased my dosage and I’m up to 1.5 pills of the highest dose. Crashing, feeling lathargic and worst part is I feel like I’m in a total and complete daze most of my entire day which is how I felt when I was 1st diagnosed. Getting nothing done at work, not motivated and in a daze.

Anyone else feel like they are in a complete daze on it?

Could I be suffering from something else besides ADHD?

Suggestions would be great. Thanks.

Reply

25 Dr Charles Parker December 2, 2007 at 11:50 AM

Addman,
From the looks of things you are slightly overweight, and have a problem with both AMP stimulants based upon a phenomenon call “tachyphylaxis.” [see a post on this interesting phenomenon coming soon]

With the metabolic issue that appears to hum in the background and the rapid tolerance to both stimulants, I would strongly suggest you ask your doc to look for other comorbid conditions. Chronic bowel problems could be one expected comorbity, for example. Don’t answer us here, but do ask yourself: “How many times a day do I go #2?”

The rapid tolerance to both drugs, especially the Vyvanse, which, from my experience has less tachyphylaxis, strongly suggests other medical problems and the need for deeper investigation.

As you know from these posts, ADD itself can present as just the tip of the iceberg, and can present as downstream swill from sleep disorder, brain injury, metabolic disorders [hypothyroid, adrenal fatigue, etc], and chronic malnutrition downstream from gluten sensitivity to name just a few.

So, best to dig deeper,
Chuck

Reply

26 theaddman December 1, 2007 at 8:48 AM

I am a 57 year-old male (6-1 and 248 lbs). I have taken Adderall 30mg, 4Xper day for the last 5 years. The dose cyle or pattern goes like this: The first week, it works great. The second week, it starts to peter out around 3pm. The third week, i start adding doses to make it through the day til at least 8pm. (my normal workday). On the fourth week I usually run out of my RX for the month. I crash for a few days, stumble around in a fog for the next couple days, and then it is time to get my monthly RX refilled. And it starts all over again. I asked to be switched to Vyvanse last month, and was started at 70mg 1X per day. It worked very well, and lasted most of my day. I was very excited about it, but then I noticed I was getting some very uncomfortable chest pain, and related indigestion. I also noticed headaches were becoming a daily event. I am in my third week of Vyvanse and am not sure if the new drug is for me or not. The jury is still out. Just FYI…

Reply

27 Dr Charles Parker November 23, 2007 at 3:42 PM

Eugene H,
As you know, it is impossible to say definitively exactly what the problem is from this distance, and yes, this is one for your doc.

In the mean time two considerations that may or may not be accurate, and are not recommendations, just thoughts:

First if you feel too sedated and somewhat toxic, most often the dose is simply too much. I have now one very sensitive adult on 1/4 of the 30mg [see the water titration post]. He is covered at that dose all day, and has several proven comorbid metabolic issues that are also in the process of resolution.

Most often a new person with Vyvanse looks for a “feeling” that it works, and in that effort can actually misinform the doc who also is carefully looking for outcome measurement tools.

The second point: Review again the cognitive outcome objective, the clear brain idea, and see if that may be the problem. When you are dosed correctly you should feel better not worse.

Yes, don’t take action on this post, – not appropriate, but do get back with your doc and perhaps reconsider the dosing strategy.
Thanks,
Chuck

Reply

28 Eugene H. November 23, 2007 at 10:02 AM

Dr. Parker,

I began treatment with Vyvance a month and a half ago, and have worked my way from 30 to 50mg. After an initial two week period where I felt amazing and unstoppable, my mood and energy seemed to slowly drain away in a smooth progression from high to low. When the dosage was raised I felt the initial pleasant effects once again, but only for three days and at a milder level.

I have been feeling depressed and I am not sure if it is a side effect of the Vyvance or if it is due to other things going on in my life. I am not usually prone to feel this way for long periods of time, but it does not seem to go away like normal sad spells. Along with that, it often feels like the Vyvance is almost sedating me. I wake up in the morning and feel energized, but about an hour after I take my medicine I am tired and withdrawn. By the end of the day (8pm) I feel I can sit still with relatively few thoughts for an hour if need be, a true rarity for me. This feeling of detachment is not just for unimportant actions; I am not bothering to communicate much with friends and I don’t feel worried about the assignments and work I have been charged with completing.

Could these be side effects of the Vyvance? I am not sure whether to see my doctor about this as soon as possible, or whether I should wait the two weeks until my next visit.

Any of your input would be appreciated.

Reply

29 Dr Charles Parker November 20, 2007 at 1:13 PM

Richard,
Some very general comments on the larger picture regarding these minimal facts in this comment:

The symptoms you describe could, of course, be related to bipolar.

My own findings in the patients I have seen, as described in detail in my posts, is that your description is also quite typical of going out the top of the window, and is more likely dose related [too much at the outset] – unless you have a mood disorder history.

Suggest you go back and follow up with your doc and review the details more carefully on the next visit.

Hope this helps,
Chuck

Reply

30 Richard November 20, 2007 at 9:15 AM

Dr. Parker:
Thanks for the excellent information. I was recently diagnosed with ADD and prescribed Vyvanse. My psychiatrist initially gave me the 70 mg. doseage then was surprised by the side effects I received (euphoria, talkativeness, excess of energy). Although I did get the positive benefits as well (ability to concentrate, exceptionally productive, no more chasing my tail type distracted behavior, etc).

He believes the negative side effects show that I do not have ADD and believes me to be bi-polar (despite no obvious signs other than occasional anxiety attacks). He states that an overprescription should have made me overly calm or have some other effect than what it did.

Long story short: it seems his advice contradicts everything I have read and heard about this drug. Any thoughts on what I should tell him?

Thanks!

Reply

Leave a Comment

Previous post:

Next post: