Bullet Proof Liver: SSRIs and Suicide

Bulletproof? Wikipedia

The Bulletproof Liver Challenge
Eleven posts since we started this series on SSRIs and suicide on Dec 13, ‘06 – addressing an article on the FDA, SSRIs and depression. The theme of these remarks: anyone can have problems with SSRIs if these 10 additional challenges go overlooked. This post takes us from an overview about brain and body, to how the brain and body function together in the office. The bulletproof liver can kill.

Sewage Treatment
From theory to practice: Sewage treatment can make a big difference in with drugs of any kind, including SSRIs. If these subtle metabolic issues are not recognized and treated, meds can encourage a rapid, dangerous turn for the worse. Yes, the downturn will, in one sense, be caused by the SSRI. With a bulletproof liver, the patient will feel that nothing works. They can feel very toxic with a small dose. But the bullet proof liver causes the problem, not the specific SSRI. Suicide can become an option.

Just yesterday saw two new women, both sophomores in high school, having suicidal thoughts on SSRIs. Both had tried numerous drugs including mood stabilizers and atypicals, all worked for awhile, or made them feel more crazy. Bulletproof liver history. Bowel problems since childhood. Both attractive, didn’t get asked the bowel frequency question.

So, just what is a bullet proof liver? Consider these physiologic essentials:

Three Treatment Plants
Your body has three main sewage treatment plants. Yes, some others are important [e.g. skin], but let’s get started by paying attention to fundamental somatic symptoms we see literally every day. Often these three systems show deterioration, even in childhood and early adolescence. Every adult evaluation should address these functional impairments.

1. Your bowel is the southern end of a food breakdown and biotransformation process that starts even before the first bite of food with enzyme production and salivation, to begin the energy transfer process. The bowel is one of the main treatment plants for the good energy coming through. If the bowel does not work well, detoxification and biotransformation of energy is interrupted. Much of what we eat here in the US is simply not good for us. [See Ultrametabolism in the sidebar here.] The plant can close down with irritable bowel, constipation, chronic use of antibiotics [even way back in childhood], infections, parasites, under or overgrowth of bad bacteria. If the bowel does not work the brain is compromised in its function. If your bowel is sick your brain is sick.

2. Your liver, another sewage treatment plant, stands next in line behind the bowel, and backs up. If the bowel is ineffective, the liver is challenged and overworked as the next downstream detox facility. The liver function becomes sick, can be “constipated” in the Phase 1 and Phase 2 biotransformation pathways. If the bowel is leaking materials, rather than detoxifying, the liver becomes frozen, – broken in it’s own function. It becomes bullet proof, meaning our psych drugs [and many other drugs and nutrients] just bounce off. They don’t get thru the first gate. The door remains closed. Toxins build up. The brain becomes even sicker. Toxins begin to spread thru brain function and body functions. Fibromyalgia, weakness, ADD, depression, anxiety, sleep disorder all sit in the cesspool. All this in the context of “normal labs.”

Those reportedly “normal labs” are only normal because they only review parts of information, the elephant’s tail. Different, more comprehensive labs tell the entire story more accurately, and can direct more specific metabolic interventions.

3. Your kidneys, the last treatment plant in the series, can also leave you unresponsive to psych meds and to SSRIs. We all know that those in dialysis are much more likely to accumulate meds and become toxic for a whole host of reasons.

While kidneys can fail to detox properly, the bowel and liver are the two most important pathways for the multiple steps in the biotransformation of psych meds. With bowel dysfunction, a downstream bulletproof liver, and possibly overloaded kidneys, trials of any meds will simply not go well. Depression and suicide can follow if we don’t address these problems at the outset.

The theme continues: Work up the entire person, find the connections, the body floats the brain.
cp

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Tagged as: ADD, Adolescence, anxiety, biotransformation, bowel, Childhood, Chronic Use of Antibiotics, Comprehensive Labs, constipation, Depression, Detoxification, Dialysis, Digestive Disorders, Evaluation, FDA, Fibromyalgia, Food and Drug Administration, infections, Irritable Bowel, kidneys, liver, mood stabilizers, Parasites, Psych medications, psych meds, Selective serotonin reuptake inhibitor, Sleep Disorder, Somatic Symptoms, SSRI, Suicidal Thoughts, Suicide, toxicity, ultrametabolism, Weakness